HitPredict

Interactor 1: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Interactor 2: PHB2 (Q99623)
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
Gene: PHB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	0.60	0.408

Property	Details
Experiments	11877444
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription GO:0051091 - positive regulation of DNA-binding transcription factor activity GO:0071456 - cellular response to hypoxia
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 299
+	Hs
		370282 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		320222 ERR2_HUMAN (25-502): 1.06e-104: 321: 19.14		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		490112 COT1_HUMAN (64-501): 4.07e-103: 317: 22.73		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		622828 COT2_HUMAN (70-501): 3.99e-101: 311: 22.35		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		1269446 ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		369087 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		369022 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93
+	Hs
		320178 ERR2_HUMAN (25-502): 1.06e-104: 321: 19.14		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		719033 ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		646250 ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70		STOM_HUMAN (1-286): 2.42e-84: 256: 17.93