HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: VAMP2 (P63027)
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)
Gene: VAMP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

The method score is based on:

Property	Details
Experiments	23100443, 29608598, 31686426, 20798282
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, cosedimentation through density gradient
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000149 - SNARE binding GO:0005543 - phospholipid binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane and 6 others more... GO:0016079 - synaptic vesicle exocytosis GO:0030672 - synaptic vesicle membrane GO:0035493 - SNARE complex assembly GO:0048471 - perinuclear region of cytoplasm GO:0048488 - synaptic vesicle endocytosis GO:0060291 - long-term synaptic potentiation
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	140
Hs

1	116

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024