Protein: SNX1
Sorting nexin-1

Gene: SNX1
Organism: Homo sapiens
Interactions: 192
UniProt ID: Q13596

Gene Ontology (top 5):
GO:0005154 - epidermal growth factor receptor binding
GO:0005158 - insulin receptor binding
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1111994

SNX6
Sorting nexin-6

9

19

Small-scale

0.973

High

1111930

SNX32
Sorting nexin-32

6

19

High-throughput

0.956

High

1112005

SNX5
Sorting nexin-5

6

19

Small-scale

0.947

High

255421

SNX2
Sorting nexin-2

5

19

Small-scale

0.926

High

1111995

DYN3
Dynamin-3

3

14

High-throughput

0.861

High

1111910

SNX1
Sorting nexin-1

3

18

Small-scale

0.835

High

1111980

BIN3
Bridging integrator 3

4

7

High-throughput

0.691

High

1111959

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

4

0

High-throughput

0.670

High

701977

TMOD1
Tropomodulin-1

3

3

High-throughput

0.667

High

1111965

CCNL2
Cyclin-L2

3

2

High-throughput

0.667

High

1111934

S35F2
Solute carrier family 35 member F2

3

1

High-throughput

0.662

High

1111960

REEP6
Receptor expression-enhancing protein 6

5

4

High-throughput

0.656

High

1111913

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

2

5

High-throughput

0.640

High

1111945

ZN397
Zinc finger protein 397

3

0

High-throughput

0.638

High

571670

HCLS1
Hematopoietic lineage cell-specific protein

2

10

High-throughput

0.628

High

900315

FXR2
RNA-binding protein FXR2

2

2

High-throughput

0.628

High

1111920

KLH10
Kelch-like protein 10

2

4

High-throughput

0.628

High

1111955

STAM1
Signal transducing adapter molecule 1

2

10

High-throughput

0.628

High

1111989

MLX
Max-like protein X

2

3

High-throughput

0.628

High

247316

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

5

High-throughput

0.618

High

1111961

SNX27
Sorting nexin-27

1

4

High-throughput

0.618

High

1111974

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.618

High

1112004

SNX8
Sorting nexin-8

1

18

Small-scale

0.618

High

1111968

LRC61
Leucine-rich repeat-containing protein 61

2

2

High-throughput

0.611

High

1111931

F90A1
Protein FAM90A1

3

3

High-throughput

0.609

High

140256

SDCB1
Syntenin-1

2

2

High-throughput

0.606

High

253079

PLIN3
Perilipin-3

2

2

High-throughput

0.606

High

1111938

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

2

1

High-throughput

0.606

High

1111950

TM239
Transmembrane protein 239

2

1

High-throughput

0.606

High

1112000

SHLB1
Endophilin-B1

2

3

High-throughput

0.606

High

1111943

TM87A
Transmembrane protein 87A

2

0

High-throughput

0.602

High

169546

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

9

Small-scale

0.595

High

218159

TGON2
Trans-Golgi network integral membrane protein 2

2

8

High-throughput

0.588

High

241615

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

630794

RAB4A
Ras-related protein Rab-4A

2

12

High-throughput

0.584

High

1111988

ZRAN1
Ubiquitin thioesterase ZRANB1

2

5

High-throughput

0.584

High

226323

SNG1
Synaptogyrin-1

2

0

High-throughput

0.580

High

922725

CCHL
Holocytochrome c-type synthase

2

0

High-throughput

0.580

High

1111949

SFT2A
Vesicle transport protein SFT2A

2

0

High-throughput

0.580

High

363248

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.576

High

281736

VP26A
Vacuolar protein sorting-associated protein 26A

1

5

Small-scale

0.575

High

1111996

GAB2
GRB2-associated-binding protein 2

1

5

High-throughput

0.575

High

1111939

CA087
Uncharacterized protein C1orf87

2

2

High-throughput

0.574

High

328912

RTN3
Reticulon-3

1

3

High-throughput

0.573

High

1111978

RTN4
Reticulon-4

1

3

High-throughput

0.573

High

1111992

PRAF1
Prenylated Rab acceptor protein 1

1

1

High-throughput

0.573

High

1085166

WASC5
WASH complex subunit 5

2

1

Small-scale

0.571

High

669385

PAR1
Proteinase-activated receptor 1

1

1

Small-scale

0.561

High

458191

ACHG
Acetylcholine receptor subunit gamma

2

1

High-throughput

0.553

High

1026997

REEP5
Receptor expression-enhancing protein 5

2

4

High-throughput

0.553

High

1111940

RDHE2
Epidermal retinol dehydrogenase 2

2

1

High-throughput

0.553

High

1112006

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

2

High-throughput

0.553

High

1111921

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.549

High

274566

DNJB6
DnaJ homolog subfamily B member 6

1

4

High-throughput

0.536

High

482613

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

5

High-throughput

0.536

High

537116

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.536

High

643195

BMP6
Bone morphogenetic protein 6

1

3

High-throughput

0.536

High

904685

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.536

High

930880

HSP72
Heat shock-related 70 kDa protein 2

1

3

High-throughput

0.536

High

933516

S12A3
Solute carrier family 12 member 3

1

3

High-throughput

0.536

High

1111918

C102B
Coiled-coil domain-containing protein 102B

1

3

High-throughput

0.536

High

1111923

STAC2
SH3 and cysteine-rich domain-containing protein 2

1

16

High-throughput

0.536

High

1111933

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

2

High-throughput

0.536

High

1111948

PRUN2
Protein prune homolog 2

1

2

High-throughput

0.536

High

1111970

DERL2
Derlin-2

1

2

High-throughput

0.536

High

1111976

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

1111981

KLHL1
Kelch-like protein 1

1

4

High-throughput

0.536

High

1111982

SPNXB
Sperm protein associated with the nucleus on the X chromosome B1

1

2

High-throughput

0.536

High

1111986

SPN90
NCK-interacting protein with SH3 domain

1

1

High-throughput

0.536

High

1111991

NRBP
Nuclear receptor-binding protein

1

3

High-throughput

0.536

High

1112001

WASC3
WASH complex subunit 3

1

1

High-throughput

0.536

High

1112002

HYOU1
Hypoxia up-regulated protein 1

1

5

High-throughput

0.536

High

873956

NRIP1
Nuclear receptor-interacting protein 1

1

0

High-throughput

0.518

High

445865

ENOA
Alpha-enolase

1

1

High-throughput

0.515

High

347008

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

585788

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

0

High-throughput

0.513

High

1111947

F200A
Protein FAM200A

1

0

High-throughput

0.513

High

49159

POTB3
POTE ankyrin domain family member B3

2

5

High-throughput

0.504

High

422070

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

484522

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1111914

DB136
Defensin beta 136

1

3

High-throughput

0.489

High

1111922

PAMR1
Inactive serine protease PAMR1

1

2

High-throughput

0.489

High

1111951

IBPL1
Insulin-like growth factor-binding protein-like 1

1

8

High-throughput

0.489

High

1111962

ODAD1
Outer dynein arm-docking complex subunit 1

1

6

High-throughput

0.489

High

1111967

ZBT18
Zinc finger and BTB domain-containing protein 18

1

7

High-throughput

0.489

High

1111975

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

6

High-throughput

0.489

High

1111999

NTNG1
Netrin-G1

1

6

High-throughput

0.489

High

1112003

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

1112007

RM42
Large ribosomal subunit protein mL42

1

1

High-throughput

0.489

High

405452

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

1111956

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.486

High

184710

ATX7
Ataxin-7

1

1

High-throughput

0.481

High

189556

STX7
Syntaxin-7

1

7

High-throughput

0.479

High

273524

DJC13
DnaJ homolog subfamily C member 13

1

12

Small-scale

0.479

High

411891

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

439727

INSR
Insulin receptor

1

20

Small-scale

0.479

High

465514

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

484134

PGFRB
Platelet-derived growth factor receptor beta

1

17

Small-scale

0.479

High

539688

ACM1
Muscarinic acetylcholine receptor M1

1

4

Small-scale

0.479

High

540441

LAMP1
Lysosome-associated membrane glycoprotein 1

1

15

High-throughput

0.479

High

541473

FGFR1
Fibroblast growth factor receptor 1

1

15

High-throughput

0.479

High

556066

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

562046

LAMP2
Lysosome-associated membrane glycoprotein 2

1

15

High-throughput

0.479

High

606738

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

618500

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

1

5

High-throughput

0.479

High

631204

RAB5A
Ras-related protein Rab-5A

1

14

High-throughput

0.479

High

675021

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.479

High

710228

EPHA2
Ephrin type-A receptor 2

1

17

High-throughput

0.479

High

720212

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.479

High

862110

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

888042

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

901226

RAB7A
Ras-related protein Rab-7a

1

19

High-throughput

0.479

High

901800

RAB9A
Ras-related protein Rab-9A

1

18

High-throughput

0.479

High

944989

RAB25
Ras-related protein Rab-25

1

10

High-throughput

0.479

High

958766

ARF3
ADP-ribosylation factor 3

1

6

High-throughput

0.479

High

962025

RHOA
Transforming protein RhoA

1

5

High-throughput

0.479

High

975023

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.479

High

976254

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.479

High

1067294

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

1094535

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

1

High-throughput

0.479

High

1111911

AVR2B
Activin receptor type-2B

1

9

Small-scale

0.479

High

1111919

LTOR1
Ragulator complex protein LAMTOR1

1

8

High-throughput

0.479

High

1111924

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

1111926

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

1111927

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1111928

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1111929

TAXB1
Tax1-binding protein 1

1

4

High-throughput

0.479

High

1111936

ZDH23
Palmitoyltransferase ZDHHC23

1

5

Small-scale

0.479

High

1111941

ARL14
ADP-ribosylation factor-like protein 14

1

8

High-throughput

0.479

High

1111944

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

1111952

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

1111953

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1111963

FMNL2
Formin-like protein 2

1

3

High-throughput

0.479

High

1111971

WWTR1
WW domain-containing transcription regulator protein 1

1

9

High-throughput

0.479

High

1111972

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

2

Small-scale

0.479

High

1111983

ZDH18
Palmitoyltransferase ZDHHC18

1

2

Small-scale

0.479

High

1111987

DJB11
DnaJ homolog subfamily B member 11

1

3

High-throughput

0.479

High

1111993

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

1111997

LAMP3
Lysosome-associated membrane glycoprotein 3

1

15

High-throughput

0.479

High

75154

FM25C
Protein FAM25C

1

1

High-throughput

0.470

High

320396

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.460

High

791371

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

920563

ARFP2
Arfaptin-2

1

0

High-throughput

0.460

High

903901

BAP31
B-cell receptor-associated protein 31

1

0

Small-scale

0.458

High

973164

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

1026366

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1111912

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1111958

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

1111977

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

1111964

VPS35
Vacuolar protein sorting-associated protein 35

1

8

Small-scale

0.457

High

142336

PEX7
Peroxisomal targeting signal 2 receptor

1

4

High-throughput

0.445

High

934577

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

967148

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

2

High-throughput

0.445

High

1111937

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

1111954

LPAR1
Lysophosphatidic acid receptor 1

1

3

High-throughput

0.445

High

1111957

P33MX
Putative monooxygenase p33MONOX

1

1

High-throughput

0.445

High

1111979

ITM2C
Integral membrane protein 2C

1

2

High-throughput

0.445

High

1111984

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

75135

FM25A
Protein FAM25A

1

1

High-throughput

0.439

High

105888

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

466892

ACM4
Muscarinic acetylcholine receptor M4

1

4

Small-scale

0.437

High

477164

ACM5
Muscarinic acetylcholine receptor M5

1

4

Small-scale

0.437

High

588641

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

695399

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

768133

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

787293

ACV1B
Activin receptor type-1B

1

9

Small-scale

0.437

High

871475

LEPR
Leptin receptor

1

4

Small-scale

0.437

High

1053454

FHI1A
FHF complex subunit HOOK-interacting protein 1A

1

5

High-throughput

0.437

High

1111935

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.437

High

1111942

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

5

High-throughput

0.437

High

330148

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

429849

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

517305

GAGE1
G antigen 1

1

1

High-throughput

0.407

High

1103952

RM49
Large ribosomal subunit protein mL49

1

3

High-throughput

0.407

High

1111966

GPX7
Glutathione peroxidase 7

2

0

High-throughput

0.328

High

339262

MPC2
Mitochondrial pyruvate carrier 2

2

0

High-throughput

0.316

High

469481

SYPH
Synaptophysin

2

0

High-throughput

0.316

High

1111917

ARM12
Armadillo repeat-containing protein 12

2

0

High-throughput

0.316

High

1111925

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

2

0

High-throughput

0.316

High

1111973

LIME1
Lck-interacting transmembrane adapter 1

2

0

High-throughput

0.316

High

1111985

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

2

0

High-throughput

0.316

High

1111932

FUND1
FUN14 domain-containing protein 1

1

0

High-throughput

0.299

High

1111915

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1111916

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.279

Low

1111969

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

1111998

DLGP4
Disks large-associated protein 4

1

0

High-throughput

0.279

Low

1111946

CC148
Coiled-coil domain-containing protein 148

1

0

High-throughput

0.251

Low

551031

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

631804

TKN1
Protachykinin-1

1

0

Small-scale

0.249

Low

720715

OXYR
Oxytocin receptor

1

0

Small-scale

0.249

Low

1111990

TKNK
Tachykinin-3

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025