HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: SYUB (Q16143)
Beta-synuclein
Gene: SNCB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.830

The method score is based on:

Property	Details
Experiments	11683992, 23630590, 32814053
Identification Methods	affinity chromatography technology, biochemical, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Synuclein~Synuclein
Common GO terms	GO:0005509 - calcium ion binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007268 - chemical synaptic transmission GO:0016234 - inclusion body and 7 others more... GO:0043025 - neuronal cell body GO:0043679 - axon terminus GO:0043524 - negative regulation of neuron apoptotic process GO:0048488 - synaptic vesicle endocytosis GO:0050808 - synapse organization GO:0051402 - neuron apoptotic process GO:1903136 - cuprous ion binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	140
Hs

1	134

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024