Interactor 1: PUR92 (P38009)
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]
Gene: ADE17
Interactor 2: PUR91 (P54113)
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]
Gene: ADE16
Species: Saccharomyces cerevisiae S288C
Source: mint
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.84 | 1.00 | 0.918 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 16554755, 18467557, 37968396, unassigned1933, 16429126 |
| Identification Methods | affinity chromatography technology, protein complementation assay, dihydrofolate reductase reconstruction, tandem affinity purification |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | AICARFT_IMPCHas~AICARFT_IMPCHas, AICARFT_IMPCHas~MGS, MGS~MGS |
| Common GO terms | GO:0003937 - IMP cyclohydrolase activity GO:0004643 - phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO:0005829 - cytosol GO:0006164 - purine nucleotide biosynthetic process GO:0006189 - 'de novo' IMP biosynthetic process |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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| + | Ec | |
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
