HitPredict

Interactor 1: RBMX (P38159)
RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]
Gene: RBMX

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	20020773, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 391 Hs			1 414
+	Hs
		161978 RBMX_HUMAN (1-367): 4.4e-45: 161: 100.00		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		745100 RBMX_HUMAN (1-367): 4.4e-45: 161: 100.00		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		1020246 ELAV2_HUMAN (10-91): 2.48e-25: 107: 29.27		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Mm
		857368 TIA1_MOUSE (2-371): 3.45e-25: 107: 14.18		TADBP_MOUSE (1-414): 1.47e-79: 253: 96.14
+	Hs
		1025728 PABP4_HUMAN (9-98): 1.43e-19: 92.6: 28.89		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		852206 PPIE_HUMAN (10-96): 1.5e-32: 126: 40.23		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		162035 PABP4_HUMAN (9-98): 1.43e-19: 92.6: 28.89		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		474019 ELAV2_HUMAN (10-91): 2.48e-25: 107: 29.27		PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96
+	Hs
		516389 RBMX_HUMAN (1-367): 4.4e-45: 161: 100.00		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		745163 RBMX_HUMAN (1-367): 4.4e-45: 161: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		516744 PPIE_HUMAN (10-96): 1.5e-32: 126: 40.23		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		1020249 ELAV2_HUMAN (10-91): 2.48e-25: 107: 29.27		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		680422 TIA1_HUMAN (2-371): 9.39e-25: 106: 14.81		TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76
+	Hs
		474021 PAB4L_HUMAN (1-180): 1.71e-21: 96.8: 18.89		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		516484 ELAV2_HUMAN (10-91): 2.48e-25: 107: 29.27		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Mm
		665745 TIA1_MOUSE (2-371): 3.45e-25: 107: 14.18		PABP1_MOUSE (2-382): 8.56e-31: 126: 15.95
+	Hs
		516495 PABP4_HUMAN (9-98): 1.43e-19: 92.6: 28.89		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		680450 TIA1_HUMAN (2-371): 9.39e-25: 106: 14.81		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Dm
		1362237 Q9VBQ1_DROME (3-88): 3.91e-19: 91: 27.91		Q9VBQ1_DROME (106-263): 1.15e-20: 96.3: 35.76