HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: MSH2 (P43246)
DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)
Gene: MSH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 0.60 0.647

The method score is based on:

Property Details
Experiments 11498787, 10783165, 15886699
Identification Methods two hybrid, pull down, biochemical, affinity chromatography technology
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003677 - DNA binding
GO:0003684 - damaged DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006281 - DNA repair
and 2 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 1863
Hs

1 934
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024