Protein: CD70
CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70)

Gene: CD70
Organism: Homo sapiens
Interactions: 168
UniProt ID: P32970

Gene Ontology (top 5):
GO:0002456 - T cell mediated immunity
GO:0005164 - tumor necrosis factor receptor binding
GO:0005886 - plasma membrane
GO:0019724 - B cell mediated immunity
GO:0033209 - tumor necrosis factor-mediated signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

689804

CD27
CD27 antigen

4

1

Small-scale

0.895

High

165793

TR13B
Tumor necrosis factor receptor superfamily member 13B

2

0

High-throughput

0.770

High

749191

TNR17
Tumor necrosis factor receptor superfamily member 17

2

0

High-throughput

0.770

High

127641

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.691

High

749179

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.656

High

749293

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.656

High

749181

NR2C2
Nuclear receptor subfamily 2 group C member 2

2

2

High-throughput

0.628

High

749205

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

2

1

High-throughput

0.628

High

749238

ZNT5
Proton-coupled zinc antiporter SLC30A5

2

1

High-throughput

0.628

High

178724

SCAM1
Secretory carrier-associated membrane protein 1

2

0

High-throughput

0.602

High

190319

COPT1
High affinity copper uptake protein 1

2

0

High-throughput

0.602

High

213309

ADCY6
Adenylate cyclase type 6

2

0

High-throughput

0.602

High

271671

HIP1R
Huntingtin-interacting protein 1-related protein

2

0

High-throughput

0.602

High

291060

UTP20
Small subunit processome component 20 homolog

2

0

High-throughput

0.602

High

732796

GLPK
Glycerol kinase

2

0

High-throughput

0.602

High

749207

TBB8
Tubulin beta-8 chain

2

0

High-throughput

0.602

High

749236

MIGA1
Mitoguardin 1

2

0

High-throughput

0.602

High

749239

EXOC6
Exocyst complex component 6

2

0

High-throughput

0.602

High

749241

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

749256

COQ8B
Atypical kinase COQ8B, mitochondrial

2

0

High-throughput

0.602

High

749273

TTYH3
Protein tweety homolog 3

2

0

High-throughput

0.602

High

749292

GPC5B
G-protein coupled receptor family C group 5 member B

2

0

High-throughput

0.602

High

749304

PLAP
Phospholipase A-2-activating protein

2

0

High-throughput

0.602

High

248841

GSDME
Gasdermin-E

2

0

High-throughput

0.576

High

251198

RNBP6
Ran-binding protein 6

2

1

High-throughput

0.574

High

522805

COT1
COUP transcription factor 1

2

2

High-throughput

0.574

High

665069

COT2
COUP transcription factor 2

2

2

High-throughput

0.574

High

749177

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

2

High-throughput

0.574

High

749180

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

2

High-throughput

0.574

High

749199

ATM
Serine-protein kinase ATM

2

1

High-throughput

0.574

High

749244

RUFY2
RUN and FYVE domain-containing protein 2

2

1

High-throughput

0.574

High

749252

FAKD4
FAST kinase domain-containing protein 4

2

1

High-throughput

0.574

High

749254

TBC20
TBC1 domain family member 20

2

1

High-throughput

0.574

High

749263

RUFY1
RUN and FYVE domain-containing protein 1

2

1

High-throughput

0.574

High

749272

XPO4
Exportin-4

2

2

High-throughput

0.574

High

749281

EI2BG
Translation initiation factor eIF2B subunit gamma

2

1

High-throughput

0.574

High

749282

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

2

2

High-throughput

0.574

High

749285

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

2

1

High-throughput

0.574

High

749297

IPO11
Importin-11

2

2

High-throughput

0.574

High

749298

XPO7
Exportin-7

2

4

High-throughput

0.574

High

749306

TNPO3
Transportin-3

2

3

High-throughput

0.574

High

749183

DYN2
Dynamin-2

1

1

High-throughput

0.536

High

749186

XPO2
Exportin-2

1

2

High-throughput

0.536

High

749193

DYN1
Dynamin-1

1

1

High-throughput

0.536

High

49588

GXLT2
Glucoside xylosyltransferase 2

1

0

High-throughput

0.513

High

230761

EXTL3
Exostosin-like 3

1

0

High-throughput

0.513

High

316485

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.513

High

722404

CTR1
High affinity cationic amino acid transporter 1

1

0

High-throughput

0.513

High

749184

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

0

High-throughput

0.513

High

749187

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

749194

PCDH1
Protocadherin-1

1

0

High-throughput

0.513

High

749201

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.513

High

749202

DAG1
Dystroglycan 1

1

0

High-throughput

0.513

High

749233

S15A4
Solute carrier family 15 member 4

1

0

Small-scale

0.513

High

749240

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.513

High

749246

ELYS
Protein ELYS

1

0

High-throughput

0.513

High

749258

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

749261

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.513

High

749265

SORT
Sortilin

1

0

High-throughput

0.513

High

749266

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

0

High-throughput

0.513

High

749286

CC50A
Cell cycle control protein 50A

1

0

High-throughput

0.513

High

749290

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

0

High-throughput

0.513

High

749294

ATX10
Ataxin-10

1

0

High-throughput

0.513

High

749301

MINP1
Multiple inositol polyphosphate phosphatase 1

1

0

High-throughput

0.513

High

749302

EXOC7
Exocyst complex component 7

1

0

High-throughput

0.513

High

164538

TNPO2
Transportin-2

1

2

High-throughput

0.489

High

220870

XPOT
Exportin-T

1

3

High-throughput

0.489

High

749182

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.489

High

749198

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.489

High

749200

ATR
Serine/threonine-protein kinase ATR

1

1

High-throughput

0.489

High

749208

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

1

High-throughput

0.489

High

749220

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

1

High-throughput

0.489

High

749280

XPO5
Exportin-5

1

4

High-throughput

0.489

High

749296

EI2BD
Translation initiation factor eIF2B subunit delta

1

1

High-throughput

0.489

High

178197

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

217884

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

728054

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

High-throughput

0.458

High

749224

HEAT3
HEAT repeat-containing protein 3

3

0

High-throughput

0.345

High

749251

GLMN
Glomulin

3

0

High-throughput

0.345

High

66140

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

2

0

High-throughput

0.328

High

136203

IFRD1
Interferon-related developmental regulator 1

2

0

High-throughput

0.328

High

185166

FANCG
Fanconi anemia group G protein

2

0

High-throughput

0.328

High

208024

TTI1
TELO2-interacting protein 1 homolog

2

0

High-throughput

0.328

High

230874

ORC5
Origin recognition complex subunit 5

2

0

High-throughput

0.328

High

261700

HUS1
Checkpoint protein HUS1

2

0

High-throughput

0.328

High

749185

NUP98
Nuclear pore complex protein Nup98-Nup96

2

0

High-throughput

0.328

High

749197

NU160
Nuclear pore complex protein Nup160

2

0

High-throughput

0.328

High

749203

UBE4A
Ubiquitin conjugation factor E4 A

2

0

High-throughput

0.328

High

749212

SYAM
Alanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.328

High

749213

DEP1A
DEP domain-containing protein 1A

2

0

High-throughput

0.328

High

749214

INT3
Integrator complex subunit 3

2

0

High-throughput

0.328

High

749215

ATLA3
Atlastin-3

2

0

High-throughput

0.328

High

749217

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

2

0

High-throughput

0.328

High

749218

INT5
Integrator complex subunit 5

2

0

High-throughput

0.328

High

749223

DYM
Dymeclin

2

0

High-throughput

0.328

High

749225

NOP9
Nucleolar protein 9

2

0

High-throughput

0.328

High

749229

RBFA
Putative ribosome-binding factor A, mitochondrial

2

0

High-throughput

0.328

High

749231

KDM8
Bifunctional peptidase and arginyl-hydroxylase JMJD5

2

0

High-throughput

0.328

High

749232

STAG2
Cohesin subunit SA-2

2

0

High-throughput

0.328

High

749237

PPTC7
Protein phosphatase PTC7 homolog

2

0

High-throughput

0.328

High

749242

CHPT1
Cholinephosphotransferase 1

2

0

High-throughput

0.328

High

749245

ATRIP
ATR-interacting protein

2

0

High-throughput

0.328

High

749247

S14L1
SEC14-like protein 1

2

0

High-throughput

0.328

High

749253

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

2

0

High-throughput

0.328

High

749259

INT4
Integrator complex subunit 4

2

0

High-throughput

0.328

High

749260

SYNM
Asparaginyl-tRNA synthetase

2

0

High-throughput

0.328

High

749269

NUP85
Nuclear pore complex protein Nup85

2

0

High-throughput

0.328

High

749275

INT2
Integrator complex subunit 2

2

0

High-throughput

0.328

High

749278

TFB2M
Dimethyladenosine transferase 2, mitochondrial

2

0

High-throughput

0.328

High

749279

NOL11
Nucleolar protein 11

2

0

High-throughput

0.328

High

749284

MDN1
Midasin

2

0

High-throughput

0.328

High

749287

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

2

0

High-throughput

0.328

High

749288

UCKL1
Uridine-cytidine kinase-like 1

2

0

High-throughput

0.328

High

749300

TIM
Protein timeless homolog

2

0

High-throughput

0.328

High

749303

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

2

0

High-throughput

0.328

High

749274

ELOV4
Very long chain fatty acid elongase 4

2

0

High-throughput

0.316

High

749257

SAAL1
Protein SAAL1

2

0

High-throughput

0.313

High

137189

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.279

Low

173667

BTAF1
TATA-binding protein-associated factor 172

1

0

High-throughput

0.279

Low

302761

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.279

Low

335602

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.279

Low

337690

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.279

Low

344395

TBCD8
TBC1 domain family member 8

1

0

High-throughput

0.279

Low

561110

GILT
Gamma-interferon-inducible lysosomal thiol reductase

1

0

High-throughput

0.279

Low

749178

VKGC
Vitamin K-dependent gamma-carboxylase

1

0

High-throughput

0.279

Low

749188

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.279

Low

749192

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

High-throughput

0.279

Low

749195

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

749196

WASC5
WASH complex subunit 5

1

0

High-throughput

0.279

Low

749204

UBE3C
Ubiquitin-protein ligase E3C

1

0

High-throughput

0.279

Low

749206

D19L1
Protein C-mannosyl-transferase DPY19L1

1

0

High-throughput

0.279

Low

749209

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

0

High-throughput

0.279

Low

749210

MKS3
Meckelin

1

0

High-throughput

0.279

Low

749211

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.279

Low

749216

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

0

High-throughput

0.279

Low

749219

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.279

Low

749221

THADA
tRNA

1

0

High-throughput

0.279

Low

749226

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

0

High-throughput

0.279

Low

749227

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.279

Low

749228

ZDH23
Palmitoyltransferase ZDHHC23

1

0

High-throughput

0.279

Low

749230

INT1
Integrator complex subunit 1

1

0

High-throughput

0.279

Low

749234

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.279

Low

749235

EFNMT
eEF1A lysine and N-terminal methyltransferase

1

0

High-throughput

0.279

Low

749243

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.279

Low

749248

S39A7
Zinc transporter SLC39A7

1

0

High-throughput

0.279

Low

749249

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.279

Low

749250

NU205
Nuclear pore complex protein Nup205

1

0

High-throughput

0.279

Low

749255

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.279

Low

749262

CP2S1
Cytochrome P450 2S1

1

0

High-throughput

0.279

Low

749264

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.279

Low

749267

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.279

Low

749268

PTSS2
Phosphatidylserine synthase 2

1

0

High-throughput

0.279

Low

749270

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.279

Low

749271

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

0

High-throughput

0.279

Low

749276

METL9
Protein-L-histidine N-pros-methyltransferase

1

0

High-throughput

0.279

Low

749277

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.279

Low

749283

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.279

Low

749289

TM160
Transmembrane protein 160

1

0

High-throughput

0.279

Low

749295

NCDN
Neurochondrin

1

0

High-throughput

0.279

Low

749299

HERC5
E3 ISG15--protein ligase HERC5

1

0

High-throughput

0.279

Low

749305

TMED5
Transmembrane emp24 domain-containing protein 5

1

0

High-throughput

0.279

Low

749307

TX264
Testis-expressed protein 264

1

0

High-throughput

0.279

Low

293278

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

749189

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low

749190

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

749222

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

749291

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

170677

CLGN
Calmegin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025