HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.722

Property	Details
Experiments	17511879, 12438214, 29764992, 22990118, 25056273
Identification Methods	affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 330
+	Hs
		737621 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PP1G_HUMAN (1-330): 0: 579: 90.66
+	Hs
		749317 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PP1B_HUMAN (1-330): 0: 568: 87.88
+	Hs
		749356 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.30
+	Hs
		737950 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		PP1G_HUMAN (1-330): 0: 579: 90.66
+	Hs
		536746 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		PP1G_HUMAN (1-330): 0: 579: 90.66
+	Hs
		738001 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		PP1G_HUMAN (1-330): 0: 579: 90.66
+	Hs
		738025 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		PP1G_HUMAN (1-330): 0: 579: 90.66