Protein: TNFL8
Tumor necrosis factor ligand superfamily member 8 (CD30 ligand) (CD30-L) (CD antigen CD153)

Gene: TNFL8, TNFSF8
Organism: Homo sapiens
Interactions: 148
UniProt ID: P32971

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005125 - cytokine activity
GO:0005164 - tumor necrosis factor receptor binding
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

749313

TNFL9
Tumor necrosis factor ligand superfamily member 9

3

0

High-throughput

0.811

High

580735

PVR
Poliovirus receptor

2

2

High-throughput

0.776

High

749326

PTPRS
Receptor-type tyrosine-protein phosphatase S

2

0

High-throughput

0.770

High

749337

CDON
Cell adhesion molecule-related/down-regulated by oncogenes

2

0

High-throughput

0.770

High

705905

TNR8
Tumor necrosis factor receptor superfamily member 8

2

0

Small-scale

0.728

High

640109

EPHA1
Ephrin type-A receptor 1

1

1

High-throughput

0.691

High

749372

NECT2
Nectin-2

1

3

High-throughput

0.691

High

749414

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.691

High

607536

PTN2
Tyrosine-protein phosphatase non-receptor type 2

3

1

High-throughput

0.662

High

749316

AGRE5
Adhesion G protein-coupled receptor E5

3

3

High-throughput

0.662

High

749361

DCBD1
Discoidin, CUB and LCCL domain-containing protein 1

3

1

High-throughput

0.662

High

749387

ULBP3
UL16-binding protein 3

3

3

High-throughput

0.662

High

749334

OCLN
Occludin

3

0

High-throughput

0.634

High

552470

FA5
Coagulation factor V

2

1

High-throughput

0.628

High

749310

RYK
Tyrosine-protein kinase RYK

2

1

High-throughput

0.628

High

749319

HBA
Hemoglobin subunit alpha

2

1

High-throughput

0.628

High

749321

EFNB1
Ephrin-B1

2

1

High-throughput

0.628

High

749333

EFNB3
Ephrin-B3

2

1

High-throughput

0.628

High

749357

FGRL1
Fibroblast growth factor receptor-like 1

2

1

High-throughput

0.628

High

749388

ULBP2
UL16-binding protein 2

2

2

High-throughput

0.628

High

749389

ULBP1
UL16-binding protein 1

2

2

High-throughput

0.628

High

335541

BMP10
Bone morphogenetic protein 10

2

1

High-throughput

0.606

High

749327

ATR
Serine/threonine-protein kinase ATR

3

1

High-throughput

0.604

High

732442

ARRB2
Beta-arrestin-2

2

0

High-throughput

0.602

High

749328

DAG1
Dystroglycan 1

2

0

High-throughput

0.602

High

749377

RB39B
Ras-related protein Rab-39B

2

0

High-throughput

0.602

High

749381

S39A3
Zinc transporter ZIP3

2

0

High-throughput

0.602

High

749391

SEM4C
Semaphorin-4C

2

0

High-throughput

0.602

High

749411

PDXL2
Podocalyxin-like protein 2

2

0

High-throughput

0.602

High

554170

BMP4
Bone morphogenetic protein 4

2

1

High-throughput

0.601

High

749398

CNNM2
Metal transporter CNNM2

2

1

High-throughput

0.601

High

749404

ITM2C
Integral membrane protein 2C

2

1

High-throughput

0.601

High

749322

CXCL9
C-X-C motif chemokine 9

2

0

High-throughput

0.580

High

749363

CADM4
Cell adhesion molecule 4

1

0

High-throughput

0.578

High

127287

LEG8
Galectin-8

2

0

High-throughput

0.576

High

749311

TGFR1
TGF-beta receptor type-1

2

0

High-throughput

0.576

High

749315

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

2

0

High-throughput

0.576

High

749366

TIP
T-cell immunomodulatory protein

2

0

High-throughput

0.576

High

749318

EPHB4
Ephrin type-B receptor 4

1

1

High-throughput

0.575

High

749382

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

2

High-throughput

0.575

High

380738

HBD
Hemoglobin subunit delta

2

1

High-throughput

0.574

High

749364

MFSD8
Major facilitator superfamily domain-containing protein 8

2

1

High-throughput

0.574

High

551959

ADT1
ADP/ATP translocase 1

1

1

High-throughput

0.536

High

565567

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.536

High

749314

MTOR
Serine/threonine-protein kinase mTOR

1

1

High-throughput

0.536

High

749335

MICB
MHC class I polypeptide-related sequence B

1

1

High-throughput

0.536

High

749336

MICA
MHC class I polypeptide-related sequence A

1

1

High-throughput

0.536

High

749338

LRC24
Leucine-rich repeat-containing protein 24

1

2

High-throughput

0.536

High

749343

AGRF1
Adhesion G-protein coupled receptor F1

1

3

High-throughput

0.536

High

749350

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

1

High-throughput

0.536

High

749353

AGRG6
Adhesion G-protein coupled receptor G6

1

3

High-throughput

0.536

High

749362

CNNM3
Metal transporter CNNM3

1

1

High-throughput

0.536

High

749375

S67A1
Solute carrier family 67 member A1

1

1

High-throughput

0.536

High

749416

AGRE2
Adhesion G protein-coupled receptor E2

1

3

High-throughput

0.536

High

749422

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.536

High

194807

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

0

High-throughput

0.513

High

249432

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.513

High

567771

TF
Tissue factor

1

0

High-throughput

0.513

High

639354

5NTD
5'-nucleotidase

1

0

High-throughput

0.513

High

749323

DDR1
Epithelial discoidin domain-containing receptor 1

1

0

High-throughput

0.513

High

749340

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

749347

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

0

High-throughput

0.513

High

749349

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.513

High

749354

NLRX1
NLR family member X1

1

0

High-throughput

0.513

High

749355

C1QL4
Complement C1q-like protein 4

1

0

High-throughput

0.513

High

749359

FBCD1
Fibrinogen C domain-containing protein 1

1

0

High-throughput

0.513

High

749384

S26A6
Solute carrier family 26 member 6

1

0

High-throughput

0.513

High

749386

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

749396

SMOC1
SPARC-related modular calcium-binding protein 1

1

0

High-throughput

0.513

High

749397

ANTR1
Anthrax toxin receptor 1

1

0

High-throughput

0.513

High

749400

LPAR2
Lysophosphatidic acid receptor 2

1

0

High-throughput

0.513

High

749403

GPC5C
G-protein coupled receptor family C group 5 member C

1

0

High-throughput

0.513

High

749410

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

0

High-throughput

0.513

High

749412

CNIH4
Protein cornichon homolog 4

1

0

High-throughput

0.513

High

749421

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.513

High

552139

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.489

High

749330

PGFRL
Platelet-derived growth factor receptor-like protein

1

1

High-throughput

0.489

High

749344

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

1

High-throughput

0.489

High

749346

SFXN4
Sideroflexin-4

1

2

High-throughput

0.489

High

749360

S2529
Mitochondrial basic amino acids transporter

1

2

High-throughput

0.489

High

749367

S2540
Mitochondrial glutathione transporter SLC25A40

1

3

High-throughput

0.489

High

749373

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

1

High-throughput

0.489

High

749378

SFXN2
Sideroflexin-2

1

2

High-throughput

0.489

High

749383

SFXN3
Sideroflexin-3

1

2

High-throughput

0.489

High

749401

TPC
Mitochondrial thiamine pyrophosphate carrier

1

2

High-throughput

0.489

High

749380

MXRA8
Matrix remodeling-associated protein 8

1

0

High-throughput

0.481

High

472000

MET
Hepatocyte growth factor receptor

1

2

High-throughput

0.445

High

749324

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.426

High

749325

PTK7
Inactive tyrosine-protein kinase 7

1

0

High-throughput

0.426

High

749420

EPCR
Endothelial protein C receptor

1

0

High-throughput

0.426

High

749424

PCDBD
Protocadherin beta-13

1

0

High-throughput

0.426

High

160812

TOR1B
Torsin-1B

3

0

High-throughput

0.345

High

749348

DHR13
Dehydrogenase/reductase SDR family member 13

3

0

High-throughput

0.345

High

749369

NEUFC
Neuferricin

3

0

High-throughput

0.345

High

296097

GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

2

0

High-throughput

0.328

High

749317

NEK3
Serine/threonine-protein kinase Nek3

2

0

High-throughput

0.328

High

749376

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

2

0

High-throughput

0.328

High

749379

CP2S1
Cytochrome P450 2S1

2

0

High-throughput

0.328

High

749415

COMD3
COMM domain-containing protein 3

2

0

High-throughput

0.328

High

143802

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

0

High-throughput

0.279

Low

164731

HS3S1
Heparan sulfate glucosamine 3-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

189116

IPO8
Importin-8

1

0

High-throughput

0.279

Low

276948

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

0

High-throughput

0.279

Low

322704

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.279

Low

335603

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.279

Low

341238

ASML
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase

1

0

High-throughput

0.279

Low

341400

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.279

Low

344458

STR3N
STARD3 N-terminal-like protein

1

0

High-throughput

0.279

Low

749308

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.279

Low

749309

MCM7
DNA replication licensing factor MCM7

1

0

High-throughput

0.279

Low

749312

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.279

Low

749320

HTRA3
Serine protease HTRA3

1

0

High-throughput

0.279

Low

749329

OXA1L
Mitochondrial inner membrane protein OXA1L

1

0

High-throughput

0.279

Low

749331

UBE3C
Ubiquitin-protein ligase E3C

1

0

High-throughput

0.279

Low

749332

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.279

Low

749339

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.279

Low

749341

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

0

High-throughput

0.279

Low

749342

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

749345

ACD10
Acyl-CoA dehydrogenase family member 10

1

0

High-throughput

0.279

Low

749351

MON2
Protein MON2 homolog

1

0

High-throughput

0.279

Low

749352

SCD5
Stearoyl-CoA desaturase 5

1

0

High-throughput

0.279

Low

749356

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.279

Low

749358

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

0

High-throughput

0.279

Low

749365

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

High-throughput

0.279

Low

749368

GPX8
Probable glutathione peroxidase 8

1

0

High-throughput

0.279

Low

749370

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

1

0

High-throughput

0.279

Low

749371

ELYS
Protein ELYS

1

0

High-throughput

0.279

Low

749374

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.279

Low

749385

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.279

Low

749390

UCK2
Uridine-cytidine kinase 2

1

0

High-throughput

0.279

Low

749392

DERL2
Derlin-2

1

0

High-throughput

0.279

Low

749393

SRR
Serine racemase

1

0

High-throughput

0.279

Low

749394

LMA2L
VIP36-like protein

1

0

High-throughput

0.279

Low

749395

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.279

Low

749399

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

749402

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

749405

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

0

High-throughput

0.279

Low

749406

AP5S1
AP-5 complex subunit sigma-1

1

0

High-throughput

0.279

Low

749407

INT7
Integrator complex subunit 7

1

0

High-throughput

0.279

Low

749408

ARL8B
ADP-ribosylation factor-like protein 8B

1

0

High-throughput

0.279

Low

749409

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.279

Low

749413

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

749417

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.279

Low

749418

TM59L
Transmembrane protein 59-like

1

0

High-throughput

0.279

Low

749419

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

0

High-throughput

0.279

Low

749423

C2CD2
C2 domain-containing protein 2

1

0

High-throughput

0.279

Low

749425

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.279

Low

322371

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025