HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: CAND1 (Q86VP6)
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
Gene: CAND1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	26831064, 34591612
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 1230
+	Hs
		268614 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		SF3B1_HUMAN (365-1153): 1.41e-55: 214: 12.32
+	Hs
		127202 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		IPO5_HUMAN (145-1127): 4.6e-35: 147: 10.95
+	Hs
		749185 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MTOR_HUMAN (11-798): 1.42e-22: 107: 11.87
+	Hs
		749726 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		GCN1_HUMAN (8-396): 2.82e-11: 70.4: 12.69
+	Hs
		749743 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TNPO1_HUMAN (826-1148): 1.51e-09: 64.6: 12.21
+	Hs
		1019328 TRI26_HUMAN (12-287): 2.53e-51: 193: 14.53		CAND1_HUMAN (1-1230): 0: 922: 100.00
+	Hs
		268854 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		SF3B1_HUMAN (365-1153): 1.41e-55: 214: 12.32