HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29656893, 37071664, 37059091
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000724 - double-strand break repair via homologous recombination GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 1834
+	Hs
		1222488 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		749197 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79
+	Hs
		749499 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54
+	Hs
		749734 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57
+	Hs
		750001 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		CABIN_HUMAN (880-1364): 9.59e-09: 63.1: 13.91
+	Hs
		1222539 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		SLX4_HUMAN (1-1834): 0: 1486: 100.00
+	Hs
		1056907 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54
+	Hs
		152673 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		KMT2D_HUMAN (889-1742): 5.87e-09: 63.6: 9.85
+	Hs
		537122 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		MAGL2_HUMAN (888-1780): 8.85e-18: 92.5: 9.81
+	Hs
		801335 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79
+	Hs
		1056954 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54