HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: SPAG5 (Q96R06)
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)
Gene: SPAG5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34591612
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007059 - chromosome segregation GO:0016604 - nuclear body
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 1193
+	Hs
		551628 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		DESP_HUMAN (501-1190): 6.44e-19: 95.8: 11.43
+	Hs
		749622 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH14_HUMAN (449-1088): 6.07e-13: 75.8: 14.74
+	Hs
		749516 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PLEC_HUMAN (462-1139): 9.56e-12: 72: 14.40
+	Hs
		725099 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH10_HUMAN (837-1188): 2.71e-11: 70.7: 11.33
+	Hs
		724691 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH9_HUMAN (873-1192): 7.59e-11: 69.1: 13.04
+	Hs
		148473 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		CTRO_HUMAN (356-721): 3.32e-10: 66.9: 9.51
+	Hs
		48078 A0AVN2_HUMAN (13-366): 3.32e-32: 138: 11.98		SPAG5_HUMAN (1-1193): 4.62e-140: 457: 100.00
+	Hs
		1300708 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		SPAG5_HUMAN (1-1193): 4.62e-140: 457: 100.00
+	Hs
		522639 TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54		MYH7_HUMAN (154-896): 6.03e-22: 105: 11.91
+	Hs
		584968 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		PLEC_HUMAN (462-1139): 9.56e-12: 72: 14.40
+	Hs
		528393 TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54		MYH6_HUMAN (958-1190): 3.59e-09: 63.7: 14.16
+	Hs
		149258 TRIM4_HUMAN (15-377): 1.5e-62: 225: 11.52		CTRO_HUMAN (356-721): 3.32e-10: 66.9: 9.51
+	Hs
		1189797 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH14_HUMAN (449-1088): 6.07e-13: 75.8: 14.74
+	Hs
		725238 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH10_HUMAN (837-1188): 2.71e-11: 70.7: 11.33
+	Hs
		725005 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH9_HUMAN (873-1192): 7.59e-11: 69.1: 13.04
+	Mm
		1093546 TRI72_MOUSE (18-91): 9.41e-12: 71.5: 30.26		MYH9_MOUSE (873-1192): 8.32e-11: 68.7: 13.67