HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.998

The method score is based on:

Property Details
Experiments 25184681, 25823446, 25652403, 28514442, 28948225, 26831064, 8944023, 11498787, 12485996, 11278247, 12732733, 14638690, 14636569, 11504724, 11526114, 10026184, 15159397, 11573085, 9738006, 27454289 and 59 others

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Identification Methods affinity chromatography technology, two hybrid, x-ray crystallography, pull down, biochemical, fluorescent resonance energy transfer, proximity labelling technology, enzymatic study, protein complementation assay, nuclear magnetic resonance and 6 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains BRCT~BRCT, zf-C3HC4~zf-RING_6
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000152 - nuclear ubiquitin ligase complex
GO:0003723 - RNA binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
and 18 others

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Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 1863
Hs

1 777
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+ Ce
+ Xl
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024