HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: CLSPN (Q9HAW4)
Claspin (hClaspin)
Gene: CLSPN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	15096610, 22863316
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0007095 - mitotic G2 DNA damage checkpoint signaling
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 1339
+	Hs
		749888 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MDN1_HUMAN (31-746): 1.29e-18: 94.8: 13.58
+	Hs
		749398 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		AKA12_HUMAN (37-1199): 5.61e-12: 73.1: 9.97
+	Hs
		749592 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		NIPBL_HUMAN (143-953): 4.88e-10: 66.7: 12.31
+	Hs
		749718 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TITIN_HUMAN (38-1005): 1.86e-09: 65: 8.69
+	Hs
		585072 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		CLSPN_HUMAN (1-1339): 0: 682: 100.00
+	Hs
		1169848 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		WDR87_HUMAN (110-1060): 9.38e-11: 69: 12.83