HitPredict - High confidence protein-protein interactions

Interactor 1: VATA (P38606)
V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)
Gene: ATP6V1A

Interactor 2: VATH (Q9UI12)
V-type proton ATPase subunit H (V-ATPase subunit H) (Nef-binding protein 1) (NBP1) (Protein VMA13 homolog) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD)
Gene: ATP6V1H

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35271311, 21674799
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0005886 - plasma membrane and 16 others more... GO:0007035 - vacuolar acidification GO:0007042 - lysosomal lumen acidification GO:0010008 - endosome membrane GO:0016020 - membrane GO:0016241 - regulation of macroautophagy GO:0030665 - clathrin-coated vesicle membrane GO:0033176 - proton-transporting V-type ATPase complex GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:0048388 - endosomal lumen acidification GO:0051452 - intracellular pH reduction GO:0061795 - Golgi lumen acidification GO:0070062 - extracellular exosome GO:0097401 - synaptic vesicle lumen acidification GO:0098850 - extrinsic component of synaptic vesicle membrane GO:1902495 - transmembrane transporter complex GO:1902600 - proton transmembrane transport
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	617
Hs

1	483

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Last updated: 15 Jul 2024