Protein: PRS4
26S proteasome regulatory subunit 4 homolog (Tat-binding homolog 5)

Gene: PRS4, RPT2
Organism: Saccharomyces cerevisiae S288C
Interactions: 146
UniProt ID: P40327

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

822411

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

25

20

Small-scale

0.989

High

750955

PRS7
26S proteasome regulatory subunit 7 homolog

17

20

Small-scale

0.988

High

803570

RPN1
26S proteasome regulatory subunit RPN1

16

20

Small-scale

0.985

High

750848

PRS6B
26S proteasome regulatory subunit 6B homolog

7

19

Small-scale

0.960

High

798558

HSM3
DNA mismatch repair protein HSM3

7

2

Small-scale

0.958

High

822446

RPN5
26S proteasome regulatory subunit RPN5

6

20

Small-scale

0.947

High

822426

PRS8
26S proteasome regulatory subunit 8 homolog

6

20

Small-scale

0.945

High

750686

PRS6A
26S proteasome regulatory subunit 6A

5

18

High-throughput

0.921

High

822412

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

4

14

High-throughput

0.896

High

822438

RPN7
26S proteasome regulatory subunit RPN7

4

20

Small-scale

0.896

High

743993

RAD23
UV excision repair protein RAD23

4

20

High-throughput

0.881

High

645177

PSB4
Proteasome subunit beta type-4

4

20

Small-scale

0.881

High

822416

PSD10
Probable 26S proteasome regulatory subunit p28

3

8

Small-scale

0.847

High

822420

PRS10
26S proteasome subunit RPT4

3

20

High-throughput

0.839

High

822441

RPN8
26S proteasome regulatory subunit RPN8

3

20

High-throughput

0.839

High

762974

SPT7
SAGA complex subunit SPT7

2

6

Small-scale

0.799

High

822404

PSMD9
Probable 26S proteasome regulatory subunit p27

2

9

Small-scale

0.767

High

509584

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

20

High-throughput

0.755

High

661414

PSA3
Proteasome subunit alpha type-3

2

20

High-throughput

0.754

High

661526

PSA2
Proteasome subunit alpha type-2

2

20

High-throughput

0.754

High

735936

PSA5
Proteasome subunit alpha type-5

2

20

High-throughput

0.754

High

822001

PSA4
Proteasome subunit alpha type-4

2

20

High-throughput

0.754

High

806734

RPN10
26S proteasome regulatory subunit RPN10

5

17

Small-scale

0.718

High

740172

RPN2
26S proteasome regulatory subunit RPN2

5

20

Small-scale

0.706

High

738315

RPN12
26S proteasome regulatory subunit RPN12

4

9

High-throughput

0.694

High

822447

RPN6
26S proteasome regulatory subunit RPN6

4

20

High-throughput

0.694

High

822429

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.691

High

314878

SEM1
26S proteasome complex subunit SEM1

4

2

Small-scale

0.683

High

822419

RPN14
26S proteasome regulatory subunit RPN14

3

12

High-throughput

0.667

High

822433

RPN9
26S proteasome regulatory subunit RPN9

3

15

High-throughput

0.662

High

803132

ECM29
Proteasome component ECM29

3

7

High-throughput

0.656

High

616428

SEC18
Vesicular-fusion protein SEC18

1

13

High-throughput

0.618

High

636589

PSA7
Probable proteasome subunit alpha type-7

1

20

High-throughput

0.618

High

636670

PSA1
Proteasome subunit alpha type-1

1

20

High-throughput

0.618

High

662046

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.618

High

668396

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.618

High

675251

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.618

High

679751

CDC48
Cell division control protein 48

1

13

High-throughput

0.618

High

721264

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.618

High

721316

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.618

High

727076

HS104
Heat shock protein 104

1

6

High-throughput

0.618

High

785930

LONM
Lon protease homolog, mitochondrial

1

19

High-throughput

0.618

High

800848

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.618

High

821968

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.618

High

822401

PRS4
26S proteasome regulatory subunit 4 homolog

1

18

High-throughput

0.618

High

150289

RPN13
26S proteasome regulatory subunit RPN13

2

2

High-throughput

0.611

High

817062

RPN3
26S proteasome regulatory subunit RPN3

2

13

High-throughput

0.601

High

670781

SIS1
Protein SIS1

2

7

High-throughput

0.584

High

792079

GBLP
Small ribosomal subunit protein RACK1

2

9

Small-scale

0.584

High

752326

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.575

High

822417

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

6

High-throughput

0.575

High

822424

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

6

High-throughput

0.575

High

579498

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.571

High

647776

RFA1
Replication factor A protein 1

1

5

High-throughput

0.536

High

793933

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

6

High-throughput

0.536

High

807228

SPT8
SAGA complex subunit SPT8

1

2

High-throughput

0.536

High

822451

SUS1
SAGA complex subunit SUS1

1

1

High-throughput

0.536

High

822408

SKP2
F-box protein SKP2

1

0

High-throughput

0.513

High

822418

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.513

High

822427

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.513

High

408416

GAL4
Regulatory protein GAL4

1

2

Small-scale

0.501

High

801841

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.501

High

822444

PUS9
tRNA pseudouridine(32) synthase, mitochondrial

1

0

High-throughput

0.493

High

518042

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

149798

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

364570

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.479

High

392821

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

435131

RS3
Small ribosomal subunit protein uS3

1

6

High-throughput

0.479

High

435998

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

464606

PBS2
MAP kinase kinase PBS2

1

8

High-throughput

0.479

High

514667

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

558750

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

603063

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.479

High

647128

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.479

High

674660

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.479

High

676645

SGF29
SAGA complex subunit SGF29

1

1

Small-scale

0.479

High

678970

NOT1
General negative regulator of transcription subunit 1

1

1

Small-scale

0.479

High

707258

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

737878

HOG1
Mitogen-activated protein kinase HOG1

1

4

High-throughput

0.479

High

738858

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

2

High-throughput

0.479

High

747889

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

763905

SPT10
Protein SPT10

1

2

High-throughput

0.479

High

764087

SPT21
Protein SPT21

1

1

High-throughput

0.479

High

778361

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

779248

CENPA
Histone H3-like centromeric protein CSE4

1

8

High-throughput

0.479

High

779996

POC2
Proteasome assembly chaperone 2

1

1

High-throughput

0.479

High

795382

ATG8
Autophagy-related protein 8

1

2

High-throughput

0.479

High

797530

UMP1
Proteasome maturation factor UMP1

1

1

High-throughput

0.479

High

802206

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

822405

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

822410

BLM10
Proteasome activator BLM10

1

5

High-throughput

0.479

High

822413

MPS3
Spindle pole body assembly component MPS3

1

2

High-throughput

0.479

High

822414

RS12
Small ribosomal subunit protein eS12

1

4

High-throughput

0.479

High

822415

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.479

High

822421

NOG2
Nucleolar GTP-binding protein 2

1

3

Small-scale

0.479

High

822422

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

8

High-throughput

0.479

High

822423

APJ1
J domain-containing protein APJ1

1

7

High-throughput

0.479

High

822425

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

822428

TOM1
E3 ubiquitin-protein ligase TOM1

1

8

High-throughput

0.479

High

822430

RPN4
Protein RPN4

1

2

Small-scale

0.479

High

822432

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.479

High

822434

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

822437

POC1
Proteasome chaperone 1

1

1

High-throughput

0.479

High

822439

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.479

High

822440

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

822445

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

822448

DBP10
ATP-dependent RNA helicase DBP10

1

8

High-throughput

0.479

High

822449

RUVB2
RuvB-like protein 2

1

5

High-throughput

0.479

High

822450

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.479

High

822435

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.460

High

440944

CDC7
Cell division control protein 7

1

20

Small-scale

0.445

High

524124

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.445

High

526839

HSP72
Heat shock protein SSA2

1

10

High-throughput

0.445

High

545084

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

676045

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.445

High

810821

TCPG
T-complex protein 1 subunit gamma

1

11

High-throughput

0.445

High

811322

CAJ1
Protein CAJ1

1

8

High-throughput

0.445

High

818902

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

822407

EMW1
Essential for maintenance of the cell wall protein 1

1

7

High-throughput

0.445

High

383732

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

410168

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

433676

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

441942

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.437

High

455098

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.437

High

503076

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504245

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

512473

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.437

High

513040

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

597985

NCPR
NADPH--cytochrome P450 reductase

1

4

High-throughput

0.437

High

677425

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.437

High

679051

FUB1
Silencing boundary-establishment protein FUB1

1

1

High-throughput

0.437

High

689490

RS7A
Small ribosomal subunit protein eS7A

1

5

High-throughput

0.437

High

747402

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

748421

SC61A
Protein transport protein SEC61

1

3

High-throughput

0.437

High

753404

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

812357

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

822402

MLP2
Protein MLP2

1

6

High-throughput

0.437

High

822406

RLP7
Ribosome biogenesis protein RLP7

1

5

High-throughput

0.437

High

822409

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

822431

ESC1
Silent chromatin protein ESC1

1

6

High-throughput

0.437

High

822442

RS10A
Small ribosomal subunit protein eS10A

1

7

High-throughput

0.437

High

822436

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.426

High

738655

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.407

High

822403

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

822443

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025