HitPredict

Interactor 1: GRP75 (P38646)
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)
Gene: HSPA9

Interactor 2: BAG1 (Q99933)
BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1)
Gene: BAG1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34428256
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BAG~HSP70
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding GO:0043066 - negative regulation of apoptotic process GO:0051085 - chaperone cofactor-dependent protein refolding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 679 Hs			1 345
+	Rn
		69526 HSP7C_RAT (51-653): 0: 883: 50.16		BAG1_RAT (1-345): 0: 518: 69.83
+	Mm
		571857 HS71B_MOUSE (51-652): 0: 868: 48.94		BAG1_MOUSE (1-345): 0: 520: 71.27
+	Hs
		504647 HSP7C_HUMAN (51-653): 0: 883: 50.16		BAG1_HUMAN (1-345): 4.2e-176: 493: 100.00
+	Hs
		714058 HS71L_HUMAN (49-673): 0: 883: 47.59		BAG1_HUMAN (1-345): 4.2e-176: 493: 100.00
+	Hs
		564166 HSP76_HUMAN (49-673): 0: 875: 48.68		BAG1_HUMAN (1-345): 4.2e-176: 493: 100.00
+	Hs
		1120588 Q53FC7_HUMAN (49-673): 0: 870: 48.37		BAG1_HUMAN (1-345): 4.2e-176: 493: 100.00
+	Hs
		871754 HSP72_HUMAN (50-653): 0: 868: 49.11		BAG1_HUMAN (1-345): 4.2e-176: 493: 100.00
+	Hs
		502474 BIP_HUMAN (53-677): 0: 566: 50.55		BAG1_HUMAN (1-345): 4.2e-176: 493: 100.00