Protein: PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)

Gene: PP6R3, PPP6R3
Organism: Homo sapiens
Interactions: 154
UniProt ID: Q5H9R7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0019888 - protein phosphatase regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

135451

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

9

8

Small-scale

0.755

High

160607

AURKA
Aurora kinase A

8

4

High-throughput

0.750

High

166945

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

3

11

Small-scale

0.671

High

1126002

GPSM1
G-protein-signaling modulator 1

3

6

Small-scale

0.656

High

749570

BRCA1
Breast cancer type 1 susceptibility protein

3

6

High-throughput

0.640

High

1126010

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

4

11

High-throughput

0.633

High

1126006

TRM2A
tRNA

2

2

High-throughput

0.628

High

1126012

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

2

11

High-throughput

0.621

High

861783

PLK1
Serine/threonine-protein kinase PLK1

2

10

High-throughput

0.611

High

1125998

MOB1B
MOB kinase activator 1B

2

8

High-throughput

0.611

High

1126044

MOB1A
MOB kinase activator 1A

2

8

High-throughput

0.611

High

1126062

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

2

6

High-throughput

0.611

High

925891

AP2B1
AP-2 complex subunit beta

2

14

High-throughput

0.595

High

835806

GSK3B
Glycogen synthase kinase-3 beta

2

9

High-throughput

0.584

High

1058222

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

7

High-throughput

0.584

High

369756

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

1126053

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.568

High

944277

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

Small-scale

0.561

High

331024

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.536

High

380305

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.536

High

439337

CATG
Cathepsin G

1

1

High-throughput

0.536

High

529222

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

675180

CLIP1
CAP-Gly domain-containing linker protein 1

1

2

High-throughput

0.536

High

804264

NOTC1
Neurogenic locus notch homolog protein 1

1

9

High-throughput

0.536

High

830384

KC1E
Casein kinase I isoform epsilon

1

3

High-throughput

0.536

High

871402

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

6

High-throughput

0.536

High

1021192

FOXD4
Forkhead box protein D4

1

7

High-throughput

0.536

High

1067508

P2RY6
P2Y purinoceptor 6

1

6

High-throughput

0.536

High

1110350

FX4L6
Forkhead box protein D4-like 6

1

7

High-throughput

0.536

High

1126014

ARRD4
Arrestin domain-containing protein 4

1

6

High-throughput

0.536

High

1126017

ARRD2
Arrestin domain-containing protein 2

1

6

High-throughput

0.536

High

1126023

HDA11
Histone deacetylase 11

1

11

High-throughput

0.536

High

1126047

E41L5
Band 4.1-like protein 5

1

4

High-throughput

0.536

High

1126050

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

1126052

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

3

High-throughput

0.536

High

1126034

SH3G3
Endophilin-A3

2

20

High-throughput

0.521

High

1126035

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.518

High

779538

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

1125997

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

4

High-throughput

0.515

High

1126021

ARHG2
Rho guanine nucleotide exchange factor 2

1

5

Small-scale

0.515

High

1126055

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.515

High

1126060

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

3

High-throughput

0.515

High

258055

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

848393

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

885546

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.513

High

1059120

ICAM4
Intercellular adhesion molecule 4

1

0

High-throughput

0.513

High

1126005

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

1126042

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.513

High

325764

LATS1
Serine/threonine-protein kinase LATS1

1

2

Small-scale

0.501

High

475872

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

435116

SP1
Transcription factor Sp1

1

4

High-throughput

0.500

High

620512

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

1

High-throughput

0.500

High

1126019

SP7
Transcription factor Sp7

1

4

High-throughput

0.500

High

135532

WN10B
Protein Wnt-10b

1

3

High-throughput

0.489

High

451997

WNT2
Protein Wnt-2

1

3

High-throughput

0.489

High

532972

PRG2
Bone marrow proteoglycan

1

2

High-throughput

0.489

High

856698

RM12
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.489

High

1126022

EMID1
EMI domain-containing protein 1

1

1

High-throughput

0.489

High

56535

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

5

High-throughput

0.479

High

121590

IKBE
NF-kappa-B inhibitor epsilon

1

16

High-throughput

0.479

High

162827

XPO1
Exportin-1

1

12

High-throughput

0.479

High

183123

KDM6A
Lysine-specific demethylase 6A

1

4

Small-scale

0.479

High

205478

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

227666

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

253748

AUXI
Auxilin

1

4

High-throughput

0.479

High

257184

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

7

High-throughput

0.479

High

262473

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

294909

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

298568

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

302165

AP2A2
AP-2 complex subunit alpha-2

1

15

High-throughput

0.479

High

321563

AP2A1
AP-2 complex subunit alpha-1

1

15

High-throughput

0.479

High

384959

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

504198

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

599678

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

6

High-throughput

0.479

High

684795

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

714542

GRK5
G protein-coupled receptor kinase 5

1

3

High-throughput

0.479

High

719347

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

1

High-throughput

0.479

High

742335

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

835394

GSK3A
Glycogen synthase kinase-3 alpha

1

9

High-throughput

0.479

High

840213

MXI1
Max-interacting protein 1

1

3

Small-scale

0.479

High

908658

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

940997

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

966250

TFAP4
Transcription factor AP-4

1

1

Small-scale

0.479

High

1014025

AP1B1
AP-1 complex subunit beta-1

1

14

High-throughput

0.479

High

1022511

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

1

High-throughput

0.479

High

1036637

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1038440

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.479

High

1039455

IRF5
Interferon regulatory factor 5

1

2

High-throughput

0.479

High

1041729

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1050216

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

7

High-throughput

0.479

High

1064380

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1066222

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1081060

CCDC6
Coiled-coil domain-containing protein 6

1

6

High-throughput

0.479

High

1101083

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1125991

TENS2
Tensin-2

1

3

High-throughput

0.479

High

1125994

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1125996

ACD11
Acyl-CoA dehydrogenase family member 11

1

2

High-throughput

0.479

High

1125999

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1126000

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1126007

STK40
Serine/threonine-protein kinase 40

1

6

Small-scale

0.479

High

1126009

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1126015

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

2

Small-scale

0.479

High

1126018

BRSK1
Serine/threonine-protein kinase BRSK1

1

7

High-throughput

0.479

High

1126020

HDAC2
Histone deacetylase 2

1

9

Small-scale

0.479

High

1126024

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1126026

TNIP3
TNFAIP3-interacting protein 3

1

3

High-throughput

0.479

High

1126028

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1126030

RB40C
Ras-related protein Rab-40C

1

4

Small-scale

0.479

High

1126032

RING2
E3 ubiquitin-protein ligase RING2

1

9

High-throughput

0.479

High

1126033

DNJC2
DnaJ homolog subfamily C member 2

1

3

High-throughput

0.479

High

1126038

WWTR1
WW domain-containing transcription regulator protein 1

1

2

High-throughput

0.479

High

1126040

DUS15
Dual specificity protein phosphatase 15

1

1

High-throughput

0.479

High

1126041

TXNIP
Thioredoxin-interacting protein

1

6

Small-scale

0.479

High

1126043

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1126045

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

1126048

MYO10
Unconventional myosin-X

1

4

Small-scale

0.479

High

1126049

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

1126051

DJC11
DnaJ homolog subfamily C member 11

1

6

High-throughput

0.479

High

1126056

KS6B2
Ribosomal protein S6 kinase beta-2

1

4

High-throughput

0.479

High

1126057

TES
Testin

1

3

High-throughput

0.479

High

1126061

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

1126063

DUS10
Dual specificity protein phosphatase 10

1

3

High-throughput

0.479

High

123617

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.458

High

208783

SNAI2
Zinc finger protein SNAI2

1

0

Small-scale

0.458

High

299910

ERLN2
Erlin-2

1

0

High-throughput

0.458

High

351395

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

649544

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

718917

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

796409

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

0

High-throughput

0.458

High

974585

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

1125992

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1125993

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

1126008

HROB
Homologous recombination OB-fold protein

1

0

Small-scale

0.458

High

1126011

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

Small-scale

0.458

High

1126016

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

1126027

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1126029

FMNL2
Formin-like protein 2

1

0

High-throughput

0.458

High

1126036

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1126039

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1126054

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

924616

GRB2
Growth factor receptor-bound protein 2

1

7

High-throughput

0.445

High

1125990

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1126013

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

1125995

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1126001

HOOK3
Protein Hook homolog 3

1

4

High-throughput

0.437

High

1126004

BRSK2
Serine/threonine-protein kinase BRSK2

1

7

High-throughput

0.437

High

1126037

CEP44
Centrosomal protein of 44 kDa

1

1

High-throughput

0.437

High

1126058

DS13B
Dual specificity protein phosphatase 13B

1

3

High-throughput

0.437

High

1126059

HOOK1
Protein Hook homolog 1

1

3

High-throughput

0.437

High

1126046

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1067

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

1126003

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

0

High-throughput

0.279

Low

1126025

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1126031

GPHA2
Glycoprotein hormone alpha-2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024