HitPredict

Interactor 1: GRP75 (P38646)
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)
Gene: HSPA9

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 679 Hs			1 729
+	Hs
		504911 HSP7C_HUMAN (51-653): 0: 883: 50.16		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		504064 HSP7C_HUMAN (51-653): 0: 883: 50.16		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		751624 GRP75_HUMAN (1-679): 0: 873: 100.00		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		1050214 Q53FC7_HUMAN (49-673): 0: 870: 48.37		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		158382 HSP7C_HUMAN (51-653): 0: 883: 50.16		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		158411 HS71L_HUMAN (49-673): 0: 883: 47.59		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		158419 GRP75_HUMAN (1-679): 0: 873: 100.00		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		254440 HSP7C_HUMAN (51-653): 0: 883: 50.16		ROCK2_HUMAN (7-724): 1.1e-114: 378: 16.52
+	Hs
		167490 GRP75_HUMAN (1-679): 0: 873: 100.00		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		504447 HSP7C_HUMAN (51-653): 0: 883: 50.16		MK15_HUMAN (1-419): 3.82e-116: 362: 17.51
+	Hs
		503460 HSP7C_HUMAN (51-653): 0: 883: 50.16		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		503902 HSP7C_HUMAN (51-653): 0: 883: 50.16		CDK3_HUMAN (6-309): 7.85e-116: 352: 20.20
+	Hs
		713942 HS71L_HUMAN (49-673): 0: 883: 47.59		CDK3_HUMAN (6-309): 7.85e-116: 352: 20.20
+	Hs
		625184 GRP75_HUMAN (1-679): 0: 873: 100.00		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		871773 HSP72_HUMAN (50-653): 0: 868: 49.11		SIK2_HUMAN (9-719): 1.2e-110: 359: 15.54
+	Dm
		669856 HSP7E_DROME (42-678): 0: 949: 77.05		IKKB_DROME (1-316): 1.37e-24: 111: 30.29
+	Dm
		669799 HSP7A_DROME (54-677): 0: 868: 47.34		IKKB_DROME (1-316): 1.37e-24: 111: 30.29
+	Dm
		505090 HSP7D_DROME (51-653): 0: 866: 50.97		IKKB_DROME (1-316): 1.37e-24: 111: 30.29
+	Sc
		477911 HSP77_YEAST (37-653): 0: 785: 66.61		RAD53_YEAST (10-221): 1.29e-22: 105: 31.65
+	Dm
		669826 BIP_DROME (53-641): 0: 566: 53.25		IKKB_DROME (1-316): 1.37e-24: 111: 30.29