HitPredict

Interactor 1: RPN1 (P38764)
26S proteasome regulatory subunit RPN1 (HMG-CoA reductase degradation protein 2) (Proteasome non-ATPase subunit 1)
Gene: RPN1

Interactor 2: DSK2 (P48510)
Ubiquitin domain-containing protein DSK2
Gene: DSK2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.958

Property	Details
Experiments	12198498, 12200120, 26912900, 34364874, 33617881, 21627799, 22318722
Identification Methods	biochemical, cross-linking study, nuclear magnetic resonance, pull down, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PC_rep~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0030674 - protein-macromolecule adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 993 Sc			1 373
+	Sc
		697080 RPN1_YEAST (1-993): 0: 1053: 100.00		RAD23_YEAST (2-370): 3.25e-51: 177: 15.25
+	Hs
		872151 PSMD2_HUMAN (2-989): 0: 1010: 34.61		RD23A_HUMAN (1-370): 2.33e-57: 192: 16.92
+	Rn
		1116239 PSMD2_RAT (2-989): 0: 1013: 34.70		RD23B_RAT (3-369): 2.17e-52: 181: 14.38
+	Hs
		872262 PSMD2_HUMAN (2-989): 0: 1010: 34.61		RD23B_HUMAN (3-369): 2.45e-50: 175: 13.70
+	At
		1195577 PSD2A_ARATH (38-992): 0: 925: 33.61		RD23C_ARATH (3-370): 3.76e-61: 203: 15.77
+	Hs
		1027821 PSMD2_HUMAN (2-989): 0: 1010: 34.61		UBQL1_HUMAN (73-370): 3.03e-20: 94.2: 17.61
+	Hs
		1027815 PSMD2_HUMAN (2-989): 0: 1010: 34.61		UBQL2_HUMAN (73-370): 4.05e-19: 90.7: 20.25
+	Hs
		1027806 PSMD2_HUMAN (2-989): 0: 1010: 34.61		UBQL4_HUMAN (74-370): 4.18e-18: 87.6: 13.64
+	Hs
		1079520 Q59EG8_HUMAN (2-989): 0: 1007: 34.61		NEDD8_HUMAN (5-71): 1.4e-21: 89.7: 39.71
+	Sp
		953205 RPN1_SCHPO (5-988): 0: 871: 37.71		DSK2_SCHPO (3-370): 1.05e-52: 180: 36.04
+	Sp
		251964 RPN1_SCHPO (5-988): 0: 871: 37.71		RHP23_SCHPO (3-369): 4.69e-51: 176: 14.70
+	Sp
		953208 RPN1_SCHPO (5-988): 0: 871: 37.71		UBP6_SCHPO (1-197): 1.25e-34: 134: 16.51
+	Hs
		872202 PSMD1_HUMAN (52-925): 0: 709: 13.42		RD23A_HUMAN (1-370): 2.33e-57: 192: 16.92
+	Hs
		872303 PSMD1_HUMAN (52-925): 0: 709: 13.42		RD23B_HUMAN (3-369): 2.45e-50: 175: 13.70
+	Rn
		292215 PSMD1_RAT (52-925): 0: 699: 13.20		RD23B_RAT (3-369): 2.17e-52: 181: 14.38
+	Dm
		1374998 Q9VW54_DROME (1-989): 0: 738: 33.30		Q9VWD9_DROME (79-367): 2.13e-21: 97.7: 18.86
+	Hs
		1303954 PSMD1_HUMAN (52-925): 0: 709: 13.42		UBQL1_HUMAN (73-370): 3.03e-20: 94.2: 17.61
+	Hs
		1303948 PSMD1_HUMAN (52-925): 0: 709: 13.42		UBQL2_HUMAN (73-370): 4.05e-19: 90.7: 20.25
+	Hs
		1303937 PSMD1_HUMAN (52-925): 0: 709: 13.42		UBQL4_HUMAN (74-370): 4.18e-18: 87.6: 13.64
+	Dm
		1359018 PSMD1_DROME (52-925): 0: 664: 13.63		Q9VWD9_DROME (79-367): 2.13e-21: 97.7: 18.86