HitPredict

Interactor 1: RPN1 (P38764)
26S proteasome regulatory subunit RPN1 (HMG-CoA reductase degradation protein 2) (Proteasome non-ATPase subunit 1)
Gene: RPN1

Interactor 2: RPN14 (P53196)
26S proteasome regulatory subunit RPN14 (Proteasome non-ATPase subunit 14)
Gene: RPN14

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.730

Property	Details
Experiments	11805837, 28137839, 19446323, 35675778, 37968396, 21658604
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, pull down, biochemical
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 993 Sc			1 417
+	Hs
		1027773 PSMD2_HUMAN (2-989): 0: 1010: 34.61		PAAF1_HUMAN (90-353): 2.5e-62: 207: 26.30
+	Sc
		753897 RPN1_YEAST (1-993): 0: 1053: 100.00		COPA_YEAST (3-403): 1.28e-29: 123: 7.57
+	Hs
		903193 PSMD2_HUMAN (2-989): 0: 1010: 34.61		WDR5_HUMAN (217-415): 1.93e-39: 145: 11.50
+	Hs
		1303913 PSMD1_HUMAN (52-925): 0: 709: 13.42		PAAF1_HUMAN (90-353): 2.5e-62: 207: 26.30
+	Sc
		693334 RPN2_YEAST (52-815): 2.95e-177: 542: 15.54		RPN14_YEAST (1-417): 2.52e-108: 327: 100.00
+	Hs
		903510 APC1_HUMAN (431-923): 4.21e-30: 131: 13.09		WDR5_HUMAN (217-415): 1.93e-39: 145: 11.50