Interactor 1: NPL4 (P33755)
Nuclear protein localization protein 4 (HMG-CoA reductase degradation protein 4)
Gene: NPL4

Interactor 2: DOA1 (P36037)
Protein DOA1 (Degradation of alpha protein 1) (Ubiquitin fusion degradation protein 3)
Gene: DOA1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 0.60 0.611

The method score is based on:

Property Details
Experiments 26349035, 16427015
Identification Methods affinity chromatography technology, biochemical
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0036435 - K48-linked polyubiquitin modification-dependent protein binding
GO:0043130 - ubiquitin binding
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
and 1 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 580
Sc

1 715
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025