HitPredict

Interactor 1: IF4A3 (P38919)
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]
Gene: EIF4A3

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	26725010, 18281698
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Hs			1 582
+	Hs
		181706 DDX3Y_HUMAN (17-410): 5.68e-143: 423: 32.45		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		571479 DDX5_HUMAN (25-411): 6.87e-135: 401: 30.63		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		1116430 DDX17_HUMAN (14-411): 1.24e-132: 399: 30.79		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		892791 IF4A1_HUMAN (7-411): 1.67e-178: 505: 66.75		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		516434 IF4A1_HUMAN (7-411): 1.67e-178: 505: 66.75		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		1031325 IF4A2_HUMAN (20-411): 4.07e-177: 501: 69.47		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		516515 IF4A2_HUMAN (20-411): 4.07e-177: 501: 69.47		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Sc
		376792 DHH1_YEAST (39-408): 1.26e-169: 486: 40.54		PABP_YEAST (9-243): 8.44e-33: 134: 13.47
+	Mm
		857295 IF4A1_MOUSE (7-411): 1.67e-178: 505: 66.75		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		516391 IF4A3_HUMAN (1-411): 1.22e-142: 414: 100.00		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Sc
		624057 DBP2_YEAST (4-409): 1.37e-135: 400: 32.37		LHP1_YEAST (7-270): 1.34e-45: 163: 22.74
+	Hs
		571585 DDX5_HUMAN (25-411): 6.87e-135: 401: 30.63		MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42
+	Hs
		134018 DDX3X_HUMAN (17-410): 2.28e-129: 388: 32.45		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		133858 DDX3X_HUMAN (17-410): 2.28e-129: 388: 32.45		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Sc
		376580 DED1_YEAST (6-411): 3.66e-130: 388: 32.00		PABP_YEAST (9-243): 8.44e-33: 134: 13.47
+	Mm
		857351 Q8BTS0_MOUSE (25-411): 7.07e-135: 401: 30.63		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		1271680 DDX17_HUMAN (14-411): 1.24e-132: 399: 30.79		RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84
+	Mm
		857323 DDX17_MOUSE (14-411): 1.34e-133: 399: 30.79		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		571469 DDX5_HUMAN (25-411): 6.87e-135: 401: 30.63		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		1077436 DDX17_HUMAN (14-411): 1.24e-132: 399: 30.79		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50