Protein: APC11
Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) (Hepatocellular carcinoma-associated RING finger protein)

Gene: APC11, ANAPC11
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q9NYG5

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0001664 - G protein-coupled receptor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

144197

UBE2C
Ubiquitin-conjugating enzyme E2 C

67

20

Small-scale

0.997

High

1162705

UBE2S
Ubiquitin-conjugating enzyme E2 S

32

20

Small-scale

0.993

High

982342

UB2D2
Ubiquitin-conjugating enzyme E2 D2

12

20

Small-scale

0.978

High

1452595

ANC2
Anaphase-promoting complex subunit 2

7

20

Small-scale

0.956

High

906800

UB2D1
Ubiquitin-conjugating enzyme E2 D1

6

20

Small-scale

0.942

High

957682

UBE2K
Ubiquitin-conjugating enzyme E2 K

3

20

Small-scale

0.845

High

957219

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.778

High

1452588

APC11
Anaphase-promoting complex subunit 11

2

6

Small-scale

0.778

High

1371883

CUL5
Cullin-5

2

20

Small-scale

0.757

High

508731

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

3

Small-scale

0.755

High

1452594

APC4
Anaphase-promoting complex subunit 4

9

1

Small-scale

0.749

High

718640

CDC27
Cell division cycle protein 27 homolog

8

10

Small-scale

0.740

High

1086919

CDC20
Cell division cycle protein 20 homolog

4

5

Small-scale

0.683

High

1332378

IQUB
IQ motif and ubiquitin-like domain-containing protein

2

0

High-throughput

0.655

High

1452596

FBX5
F-box only protein 5

1

2

Small-scale

0.647

High

1452597

FZR1
Fizzy-related protein homolog

3

5

Small-scale

0.646

High

353827

PTTG1
Securin

3

0

Small-scale

0.627

High

1218764

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

1093068

CDC16
Cell division cycle protein 16 homolog

3

11

Small-scale

0.624

High

1447689

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

20

Small-scale

0.618

High

225708

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

1

High-throughput

0.606

High

930807

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

1

High-throughput

0.606

High

1039826

CREB5
Cyclic AMP-responsive element-binding protein 5

2

3

High-throughput

0.606

High

1419116

KRA33
Keratin-associated protein 3-3

2

1

High-throughput

0.606

High

1419140

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.606

High

1452598

APC10
Anaphase-promoting complex subunit 10

2

5

Small-scale

0.595

High

1061902

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1186541

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.580

High

1186610

KRA61
Keratin-associated protein 6-1

2

0

High-throughput

0.580

High

1186716

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

1198055

KR132
Keratin-associated protein 13-2

2

0

High-throughput

0.580

High

1289320

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

1307070

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.580

High

1331111

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

0

High-throughput

0.580

High

1332057

BANP
Protein BANP

2

0

High-throughput

0.580

High

1336966

BEND2
BEN domain-containing protein 2

2

0

High-throughput

0.580

High

1372107

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.580

High

1397220

SMIP9
Protein SPMIP9

2

0

High-throughput

0.580

High

1452589

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

1452591

CDC23
Cell division cycle protein 23 homolog

2

11

Small-scale

0.571

High

350507

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

3

High-throughput

0.553

High

351610

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

2

High-throughput

0.553

High

1086451

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

2

2

High-throughput

0.553

High

1351667

OXER1
Oxoeicosanoid receptor 1

2

2

High-throughput

0.553

High

1431770

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

1

High-throughput

0.553

High

635009

MAK
Serine/threonine-protein kinase MAK

1

1

High-throughput

0.541

High

1245068

TRI65
E3 ubiquitin-protein ligase TRIM65

1

1

High-throughput

0.541

High

1252782

RN111
E3 ubiquitin-protein ligase Arkadia

1

3

High-throughput

0.541

High

219754

FOXO3
Forkhead box protein O3

1

0

Small-scale

0.537

High

162049

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

2

High-throughput

0.536

High

625669

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.536

High

1007460

S35B1
Solute carrier family 35 member B1

1

1

High-throughput

0.536

High

849083

ZAP70
Tyrosine-protein kinase ZAP-70

1

0

High-throughput

0.518

High

1332995

MLKL
Mixed lineage kinase domain-like protein

1

0

High-throughput

0.518

High

231774

PEX1
Peroxisomal ATPase PEX1

1

7

High-throughput

0.515

High

1407600

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.513

High

419243

H2A1B
Histone H2A type 1-B/E

1

4

Small-scale

0.501

High

573900

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.501

High

755007

H2B1B
Histone H2B type 1-B

1

2

Small-scale

0.501

High

998880

H31
Histone H3.1

1

0

Small-scale

0.480

High

629166

CCNA2
Cyclin-A2

1

2

Small-scale

0.479

High

1029161

E2F1
Transcription factor E2F1

1

1

Small-scale

0.479

High

1220849

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

1430903

APC1
Anaphase-promoting complex subunit 1

1

2

Small-scale

0.479

High

1452590

HERC5
E3 ISG15--protein ligase HERC5

1

3

Small-scale

0.479

High

1452592

APC7
Anaphase-promoting complex subunit 7

1

11

Small-scale

0.479

High

1452593

APC5
Anaphase-promoting complex subunit 5

1

1

Small-scale

0.479

High

1045845

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

70514

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

220312

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.316

High

922371

CRBA2
Beta-crystallin A2

2

0

High-throughput

0.316

High

1278580

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

0

High-throughput

0.316

High

1452599

CAN11
Calpain-11

1

0

High-throughput

0.282

High

1363791

YLAT2
Y+L amino acid transporter 2

1

0

High-throughput

0.279

Low

705583

GRN
Progranulin

1

0

High-throughput

0.268

Low

1191406

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

1379907

NKD2
Protein naked cuticle homolog 2

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025