Interactor 1: FEN1 (P39748)
Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1)
Gene: FEN1
Interactor 2: WRN (Q14191)
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]
Gene: WRN
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.85 | 0.60 | 0.717 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 14688284, 16326861, 11598021, 14657243 |
| Identification Methods | pull down, affinity chromatography technology, fluorescent resonance energy transfer, anti bait coimmunoprecipitation, enzyme linked immunosorbent assay, coimmunoprecipitation |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0000287 - magnesium ion binding GO:0000724 - double-strand break repair via homologous recombination GO:0000781 - chromosome, telomeric region GO:0003677 - DNA binding GO:0004527 - exonuclease activity and 7 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
