HitPredict

Interactor 1: GLE2 (P40066)
mRNA export factor GLE2 (Nuclear pore protein GLE2) (Nucleoporin GLE2) (poly(A) RNA export protein RAE1)
Gene: GLE2

Interactor 2: NU159 (P40477)
Nucleoporin NUP159 (Nuclear pore protein NUP159)
Gene: NUP159

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	16429126, 15741174, 33333025, 18046405
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0006913 - nucleocytoplasmic transport GO:0016973 - poly(A)+ mRNA export from nucleus GO:0031965 - nuclear membrane and 1 others more... GO:0051664 - nuclear pore localization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 365 Sc			1 1460
+	At
		1105208 RAE1_ARATH (17-364): 2.24e-103: 309: 39.55		NU98A_ARATH (330-1125): 1.02e-25: 117: 12.27
+	Mm
		1161320 RAE1L_MOUSE (16-365): 1.23e-92: 283: 40.34		NUP98_MOUSE (549-1298): 1.23e-25: 117: 13.15
+	Hs
		857963 RAE1L_HUMAN (1-365): 8.11e-95: 288: 40.27		NUP98_HUMAN (569-1203): 3.25e-23: 109: 13.08
+	At
		96168 RAE1_ARATH (17-364): 2.24e-103: 309: 39.55		NU98B_ARATH (367-967): 1.94e-15: 84: 13.31
+	At
		1105232 RAE1_ARATH (17-364): 2.24e-103: 309: 39.55		NUP1_ARATH (406-876): 2e-09: 64.5: 19.59
+	Dm
		1362947 RAE1_DROME (24-362): 1.1e-81: 254: 41.33		NUP98_DROME (404-1160): 5.17e-24: 112: 12.59
+	Hs
		211213 BUB3_HUMAN (26-363): 4.13e-92: 280: 33.63		KMT2C_HUMAN (436-1012): 1.38e-15: 85.2: 11.07
+	Hs
		727239 RAE1L_HUMAN (1-365): 8.11e-95: 288: 40.27		NU214_HUMAN (401-760): 2.01e-09: 64.9: 17.80
+	Ce
		106866 BUB3_CAEEL (26-362): 4.45e-94: 286: 31.20		NUP98_CAEEL (349-596): 2.37e-09: 64.4: 14.61
+	Xl
		1150105 Q7ZZY7_XENLA (21-365): 2.04e-92: 282: 42.61		Q6DCP4_XENLA (428-887): 8.02e-10: 65.3: 17.45
+	Sc
		541884 GLE2_YEAST (1-365): 2.25e-83: 259: 100.00		NSP1_YEAST (404-1068): 4.68e-16: 86.1: 19.91
+	Dm
		113998 Q9W1T0_DROME (26-353): 3.19e-74: 235: 27.76		M9PB30_DROME (59-728): 6.65e-22: 106: 9.01
+	Sc
		767628 GLE2_YEAST (1-365): 2.25e-83: 259: 100.00		NU100_YEAST (414-1004): 1.29e-12: 74.9: 16.82
+	Sc
		767622 GLE2_YEAST (1-365): 2.25e-83: 259: 100.00		NUP42_YEAST (433-688): 7.05e-12: 71.5: 19.37
+	Hs
		1147485 NLE1_HUMAN (214-363): 1.04e-26: 112: 11.92		ARID2_HUMAN (191-1192): 5.49e-13: 76.4: 9.58
+	Dm
		1358850 WDS_DROME (2-68): 6.34e-11: 65.1: 10.15		NUP98_DROME (404-1160): 5.17e-24: 112: 12.59
+	Hs
		1147471 SNR40_HUMAN (251-359): 3.31e-21: 95.1: 14.55		ARID2_HUMAN (191-1192): 5.49e-13: 76.4: 9.58
+	Hs
		72754 SNR40_HUMAN (251-359): 3.31e-21: 95.1: 14.55		B4DET5_HUMAN (389-1160): 4.01e-12: 73.4: 10.39
+	Hs
		1288235 SNR40_HUMAN (251-359): 3.31e-21: 95.1: 14.55		P121A_HUMAN (412-889): 8.39e-12: 72.2: 16.51
+	Mm
		903669 WDR5_MOUSE (2-67): 7.82e-10: 61.6: 10.29		KMT2C_MOUSE (379-1191): 2.06e-19: 97.9: 11.39