Protein: PTN7
Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP)

Gene: PTN7, PTPN7
Organism: Homo sapiens
Interactions: 66
UniProt ID: P35236

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703458

MK01
Mitogen-activated protein kinase 1

7

20

Small-scale

0.754

High

691646

MK03
Mitogen-activated protein kinase 3

5

20

Small-scale

0.724

High

767053

MK14
Mitogen-activated protein kinase 14

5

20

Small-scale

0.711

High

362867

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.698

High

465429

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.698

High

641501

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.698

High

767047

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.698

High

767050

PTK7
Inactive tyrosine-protein kinase 7

1

20

High-throughput

0.698

High

767051

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.698

High

710095

EPHA2
Ephrin type-A receptor 2

1

19

High-throughput

0.625

High

767063

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.625

High

767036

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

19

High-throughput

0.618

High

767040

DHYS
Deoxyhypusine synthase

2

2

High-throughput

0.611

High

767071

GMCL1
Germ cell-less protein-like 1

3

2

High-throughput

0.597

High

767056

CCD57
Coiled-coil domain-containing protein 57

1

2

High-throughput

0.573

High

245431

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

1

High-throughput

0.536

High

354565

PAK4
Serine/threonine-protein kinase PAK 4

1

5

High-throughput

0.536

High

761334

HS71L
Heat shock 70 kDa protein 1-like

1

2

High-throughput

0.536

High

767037

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.536

High

767070

HS105
Heat shock protein 105 kDa

1

6

High-throughput

0.536

High

281900

MPPB
Mitochondrial-processing peptidase subunit beta

2

3

High-throughput

0.533

High

767049

MPPA
Mitochondrial-processing peptidase subunit alpha

2

3

High-throughput

0.533

High

767039

MAOX
NADP-dependent malic enzyme

1

0

High-throughput

0.513

High

421601

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

767043

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

Small-scale

0.501

High

605573

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

Small-scale

0.480

High

251199

RNBP6
Ran-binding protein 6

1

8

High-throughput

0.479

High

717700

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

9

High-throughput

0.479

High

767038

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

767042

DCAF7
DDB1- and CUL4-associated factor 7

1

2

High-throughput

0.479

High

767044

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

2

High-throughput

0.479

High

767045

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

2

High-throughput

0.479

High

767052

MK11
Mitogen-activated protein kinase 11

1

20

High-throughput

0.479

High

767054

RBBP7
Histone-binding protein RBBP7

1

2

High-throughput

0.479

High

767055

MAPK3
MAP kinase-activated protein kinase 3

1

4

High-throughput

0.479

High

767057

PPCEL
Prolyl endopeptidase-like

1

3

High-throughput

0.479

High

767059

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

1

High-throughput

0.479

High

767061

DCA10
DDB1- and CUL4-associated factor 10

1

1

High-throughput

0.479

High

767062

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

2

High-throughput

0.479

High

767065

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

4

High-throughput

0.479

High

767066

AROS
Active regulator of SIRT1

1

1

High-throughput

0.479

High

767069

IPO4
Importin-4

1

9

High-throughput

0.479

High

767073

MACD1
ADP-ribose glycohydrolase MACROD1

1

1

High-throughput

0.479

High

767076

SAV1
Protein salvador homolog 1

1

2

High-throughput

0.479

High

767078

ARMX3
Armadillo repeat-containing X-linked protein 3

1

1

High-throughput

0.479

High

767058

Q53SE7
Germ cell-less homolog 1

1

2

High-throughput

0.470

High

61043

FUCM
Fucose mutarotase

1

0

High-throughput

0.458

High

229971

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.458

High

316765

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.458

High

351082

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.458

High

593640

BGAL
Beta-galactosidase

1

0

High-throughput

0.458

High

673804

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

767041

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.458

High

767064

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

767067

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

High-throughput

0.458

High

767072

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

767074

MEP50
Methylosome protein WDR77

1

0

High-throughput

0.458

High

767075

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

767046

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

5

Small-scale

0.457

High

618224

CADH2
Cadherin-2

1

20

High-throughput

0.445

High

767060

PREP
Presequence protease, mitochondrial

1

3

High-throughput

0.437

High

767068

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

3

High-throughput

0.437

High

767077

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

4

High-throughput

0.437

High

767079

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.437

High

767048

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025