HitPredict

Interactor 1: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	9013873
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 918 Hs			1 217
+	Hs
		548653 IL6RB_HUMAN (1-918): 0: 623: 100.00		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		442787 IL6RB_HUMAN (1-918): 0: 623: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		924809 CSF3R_HUMAN (1-818): 1.84e-103: 342: 24.91		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		770716 CSF3R_MOUSE (1-793): 1.35e-98: 329: 22.33		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Mm
		411919 CSF3R_MOUSE (1-793): 1.35e-98: 329: 22.33		LCK_MOUSE (3-202): 2.89e-37: 137: 28.44
+	Hs
		411565 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		645942 CNTFR_HUMAN (39-326): 4.17e-50: 183: 22.11		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		442875 CSF3R_HUMAN (1-818): 1.84e-103: 342: 24.91		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433961 CSF3R_HUMAN (1-818): 1.84e-103: 342: 24.91		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Mm
		435879 CSF3R_MOUSE (1-793): 1.35e-98: 329: 22.33		HCK_MOUSE (119-215): 2.26e-11: 64.2: 23.23
+	Mm
		56907 PTPRF_MOUSE (32-733): 3.86e-85: 301: 15.40		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		411959 PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Dm
		337644 LAR_DROME (115-849): 8.92e-58: 219: 11.42		ABL_DROME (4-135): 1e-22: 97.4: 37.68
+	Hs
		412016 PTPRD_HUMAN (1-897): 2.19e-59: 223: 11.86		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		557612 CNTFR_HUMAN (39-326): 4.17e-50: 183: 22.11		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337354 CNTFR_HUMAN (39-326): 4.17e-50: 183: 22.11		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		548629 PRLR_HUMAN (124-351): 1.32e-50: 190: 25.83		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		434111 ROBO1_HUMAN (6-512): 1.04e-51: 199: 11.25		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		412029 CNTFR_HUMAN (39-326): 4.17e-50: 183: 22.11		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		560471 PRLR_HUMAN (124-351): 1.32e-50: 190: 25.83		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18