HitPredict

Interactor 1: PSA2 (P40301)
Proteasome subunit alpha type-2 (PROS-Dm25) (Proteasome 25 kDa subunit)
Gene: Prosalpha2

Interactor 2: Q9W414 (Q9W414)
Regulatory particle triple-A ATPase 4 (EC 3.6.1.3)
Gene: Rpt4

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA_lid_3~Proteasome, AAA~Proteasome_A_N, AAA_lid_3~Proteasome_A_N
Common GO terms	GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 234 Dm			1 397
+	Dm
		820495 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		PRS4_DROME (13-388): 2.71e-153: 441: 42.41
+	Dm
		1278655 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		Q9W414_DROME (1-397): 4.61e-139: 404: 100.00
+	Hs
		656196 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PRS10_HUMAN (11-397): 1.65e-137: 399: 88.89
+	Hs
		637669 PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11		PRS10_HUMAN (11-397): 1.65e-137: 399: 88.89
+	Hs
		656193 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PRS4_HUMAN (14-388): 5.77e-133: 390: 42.26
+	Ce
		184351 PSA2_CAEEL (4-233): 3.6e-99: 289: 60.35		PRS10_CAEEL (4-397): 2.14e-132: 387: 80.96
+	Hs
		637667 PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11		PRS4_HUMAN (14-388): 5.77e-133: 390: 42.26
+	Dm
		186129 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		PRS8_DROME (1-395): 1.66e-124: 367: 44.94
+	Hs
		656167 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PRS6B_HUMAN (7-391): 7.81e-123: 363: 42.60
+	Dm
		1278638 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		Q9V405_DROME (3-391): 1.27e-122: 362: 40.62
+	Dm
		186105 PSA2_DROME (1-234): 2.1e-95: 280: 100.00		PRS8_DROME (1-395): 1.66e-124: 367: 44.94
+	Hs
		656194 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PRS8_HUMAN (14-395): 1.08e-120: 357: 46.60
+	Hs
		637642 PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11		PRS6B_HUMAN (7-391): 7.81e-123: 363: 42.60
+	Rn
		566253 PSA2_RAT (1-233): 2.22e-95: 280: 77.68		PRS8_RAT (14-395): 1.08e-120: 357: 46.60
+	Hs
		637668 PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11		PRS8_HUMAN (14-395): 1.08e-120: 357: 46.60
+	Hs
		656158 PSA5_HUMAN (1-233): 1.45e-98: 288: 31.38		PRS7_HUMAN (12-382): 2.39e-109: 329: 45.22
+	Dm
		1181022 PSA5_DROME (1-233): 1.55e-97: 286: 30.71		Q7KMQ0_DROME (12-382): 2.27e-109: 329: 45.22
+	Sp
		194879 PSA5_SCHPO (1-231): 3.4e-100: 293: 32.77		PRS7_SCHPO (74-394): 1.8e-106: 322: 49.69
+	Hs
		637639 PSA2_HUMAN (1-233): 1.3e-95: 280: 78.11		PRS7_HUMAN (12-382): 2.39e-109: 329: 45.22
+	Zm
		32495 A0A1D6Q5L0_MAIZE (7-233): 7.13e-94: 284: 61.40		A0A1D6KUI9_MAIZE (124-374): 1.15e-79: 262: 41.43