HitPredict

Interactor 1: PSA4 (P40303)
Proteasome subunit alpha type-4 (Macropain subunit PRE6) (Multicatalytic endopeptidase complex subunit PRE6) (Proteasome component PRE6) (Proteinase YSCE subunit PRE6)
Gene: PRE6

Interactor 2: RPN8 (Q08723)
26S proteasome regulatory subunit RPN8
Gene: RPN8

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	16429126, 19412159, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0034515 - proteasome storage granule GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 254 Sc			1 338
+	Dm
		640776 PSA5_DROME (2-237): 3.02e-91: 270: 31.28		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Sp
		251462 PSA4_SCHPO (1-252): 1.7e-93: 277: 55.95		RPN8_SCHPO (5-321): 6.04e-99: 296: 50.78
+	Dm
		611629 PSA71_DROME (2-233): 1.09e-88: 264: 51.72		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Hs
		638089 PSA4_HUMAN (3-233): 8.68e-91: 270: 31.49		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		849173 PSA6_HUMAN (2-239): 6.82e-91: 270: 29.75		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		637362 PSA1_HUMAN (2-249): 6.06e-90: 268: 31.35		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Hs
		656177 PSA5_HUMAN (2-236): 2.2e-90: 268: 32.92		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Mm
		643130 PSA1_MOUSE (2-248): 2.48e-89: 266: 31.47		PSMD7_MOUSE (6-301): 3.65e-97: 292: 50.51
+	Sc
		619393 PSA3_YEAST (4-207): 3.34e-40: 140: 35.29		RPN8_YEAST (1-338): 6.52e-119: 348: 100.00
+	Sp
		784770 PSA4_SCHPO (1-252): 1.7e-93: 277: 55.95		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Sp
		784781 PSA5_SCHPO (2-239): 2.2e-93: 276: 36.48		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Sp
		784767 PSA3_SCHPO (1-243): 1.64e-92: 274: 32.93		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Dm
		640767 PSA2_DROME (4-214): 9.25e-44: 149: 40.28		PSMD7_DROME (4-325): 8.23e-103: 307: 45.68
+	Hs
		637651 PSA2_HUMAN (3-236): 1.56e-45: 154: 38.14		PSMD7_HUMAN (6-301): 2.63e-97: 292: 50.51
+	Dm
		1278634 PSA5_DROME (2-237): 3.02e-91: 270: 31.28		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Dm
		611650 PSA71_DROME (2-233): 1.09e-88: 264: 51.72		PSDE_DROME (3-264): 6.45e-48: 165: 16.90
+	Sp
		293712 PSA2_SCHPO (4-236): 5.42e-40: 140: 39.11		RPN11_SCHPO (1-263): 3.34e-61: 199: 19.11
+	Dm
		771306 PSA2_DROME (4-214): 9.25e-44: 149: 40.28		PSDE_DROME (3-264): 6.45e-48: 165: 16.90