HitPredict

Interactor 1: VHL (P40337)
von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
Gene: VHL

Interactor 2: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	32814053, 17353931
Identification Methods	two hybrid array, two hybrid pooling approach, anti bait coimmunoprecipitation, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 213 Hs			1 200
+	Hs
		771845 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74
+	Hs
		771887 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06
+	Hs
		771862 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74
+	Hs
		771865 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		UBE2N_HUMAN (27-153): 1.06e-37: 129: 51.97