Protein: CBS
Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase)

Gene: CBS
Organism: Homo sapiens
Interactions: 134
UniProt ID: P35520

Gene Ontology (top 5):
GO:0001958 - endochondral ossification
GO:0001974 - blood vessel remodeling
GO:0004122 - cystathionine beta-synthase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

771857

CBS
Cystathionine beta-synthase

9

19

Small-scale

0.972

High

771866

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.702

High

771872

UBC9
SUMO-conjugating enzyme UBC9

4

1

Small-scale

0.694

High

297762

PIAS2
E3 SUMO-protein ligase PIAS2

3

2

High-throughput

0.667

High

771865

FXR2
RNA-binding protein FXR2

3

1

High-throughput

0.666

High

771939

ZMYM5
Zinc finger MYM-type protein 5

3

0

High-throughput

0.639

High

680791

PSA1
Proteasome subunit alpha type-1

2

0

High-throughput

0.601

High

771869

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

0

High-throughput

0.601

High

771882

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

High-throughput

0.601

High

771886

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

0

High-throughput

0.586

High

771907

HID1
Protein HID1

2

0

High-throughput

0.582

High

771932

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

2

0

High-throughput

0.582

High

771892

RHGBB
Inactive Rho GTPase-activating protein 11B

2

2

High-throughput

0.571

High

771893

RHG29
Rho GTPase-activating protein 29

2

4

High-throughput

0.571

High

771876

ECHP
Peroxisomal bifunctional enzyme

2

0

High-throughput

0.571

High

771900

Q7KZS0
SUMO-conjugating enzyme UBC9

2

1

High-throughput

0.558

High

771914

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

2

0

High-throughput

0.547

High

771919

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

771862

ATRX
Transcriptional regulator ATRX

1

2

High-throughput

0.541

High

771864

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

771905

HIPK1
Homeodomain-interacting protein kinase 1

1

3

High-throughput

0.541

High

771929

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

2

High-throughput

0.541

High

771941

FAF1
FAS-associated factor 1

1

2

High-throughput

0.541

High

771920

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

0

High-throughput

0.536

High

472485

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.518

High

685114

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.518

High

771874

SATB1
DNA-binding protein SATB1

1

0

High-throughput

0.518

High

771888

UGPA
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.518

High

771890

ZN181
Zinc finger protein 181

1

0

High-throughput

0.518

High

771908

SLF2
SMC5-SMC6 complex localization factor protein 2

1

0

High-throughput

0.518

High

771946

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.518

High

771947

CERT
Ceramide transfer protein

1

0

High-throughput

0.518

High

605576

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.515

High

169461

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.501

High

185476

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

771906

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.494

High

482841

TPM1
Tropomyosin alpha-1 chain

1

0

High-throughput

0.493

High

771867

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.493

High

276676

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

0

High-throughput

0.493

High

440412

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.493

High

764481

CTNB1
Catenin beta-1

1

0

High-throughput

0.493

High

771861

HD
Huntingtin

1

0

High-throughput

0.493

High

771887

CYH1
Cytohesin-1

1

0

High-throughput

0.493

High

771917

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

771944

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.493

High

531011

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

0

High-throughput

0.486

High

297477

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

Small-scale

0.481

High

67628

RHG32
Rho GTPase-activating protein 32

1

4

High-throughput

0.479

High

240904

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

345442

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

507607

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

532406

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

667589

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

731012

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

771858

MSX2
Homeobox protein MSX-2

1

1

High-throughput

0.479

High

771884

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

771889

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

771898

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

771901

ZFY16
Zinc finger FYVE domain-containing protein 16

1

1

Small-scale

0.479

High

771904

GPSM1
G-protein-signaling modulator 1

1

3

Small-scale

0.479

High

771910

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.479

High

771913

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

771915

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.479

High

771916

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

771924

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

771930

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

771931

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

771934

RHG35
Rho GTPase-activating protein 35

1

3

High-throughput

0.479

High

771940

RHG26
Rho GTPase-activating protein 26

1

4

High-throughput

0.479

High

129673

CBX4
E3 SUMO-protein ligase CBX4

1

0

Small-scale

0.460

High

771859

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

771923

RANB9
Ran-binding protein 9

1

0

Small-scale

0.460

High

771936

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.460

High

771937

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.460

High

128810

MEN1
Menin

1

0

High-throughput

0.458

High

131770

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

257360

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

293293

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

315205

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319458

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

349835

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

411472

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

588047

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

694761

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

767110

MERL
Merlin

1

0

High-throughput

0.458

High

771860

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

771868

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.458

High

771870

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

771871

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

771873

E2F1
Transcription factor E2F1

1

0

Small-scale

0.458

High

771875

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

771878

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

771879

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

771881

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

771883

CUL3
Cullin-3

1

0

High-throughput

0.458

High

771885

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

771896

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

771902

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

771912

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

771918

OPTN
Optineurin

1

0

High-throughput

0.458

High

771921

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

771922

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

771925

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

771926

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

771935

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

771938

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

771942

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

327831

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

468126

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.445

High

567276

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.445

High

771943

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

771948

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

Small-scale

0.439

High

771877

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

High-throughput

0.437

High

771899

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.437

High

771909

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

771928

ASXL3
Putative Polycomb group protein ASXL3

1

2

High-throughput

0.437

High

437632

HEPS
Serine protease hepsin

1

0

High-throughput

0.426

High

536619

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

771895

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

771897

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

771927

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

649176

GALA
Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide

1

0

High-throughput

0.268

Low

105454

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

767542

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

771863

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

771891

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.249

Low

771911

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

771945

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

388609

C1QA
Complement C1q subcomponent subunit A

1

0

High-throughput

0.232

Low

771880

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

771894

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.232

Low

771903

TMM25
Transmembrane protein 25

1

0

High-throughput

0.232

Low

771933

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025