HitPredict

Interactor 1: VHL (P40337)
von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
Gene: VHL

Interactor 2: UBP33 (Q8TEY7)
Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)
Gene: USP33

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	11739384, 19706539
Identification Methods	enzymatic study, two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0030891 - VCB complex GO:0050821 - protein stabilization
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 213 Hs			1 942
+	Hs
		772211 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		UBP20_HUMAN (32-942): 0: 778: 58.27
+	Hs
		772000 VHL_HUMAN (1-213): 3.45e-146: 407: 100.00		UBP39_HUMAN (596-722): 8.74e-36: 145: 27.91