Protein: K2C6C
Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12)

Gene: K2C6C, KRT6C
Organism: Homo sapiens
Interactions: 96
UniProt ID: P48668

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005882 - intermediate filament
GO:0030280 - structural constituent of skin epidermis
GO:0031424 - keratinization
GO:0045095 - keratin filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

436822

K1C18
Keratin, type I cytoskeletal 18

5

20

High-throughput

0.918

High

300734

KRT38
Keratin, type I cuticular Ha8

3

20

High-throughput

0.871

High

876476

K1H1
Keratin, type I cuticular Ha1

3

20

High-throughput

0.871

High

876481

K1C40
Keratin, type I cytoskeletal 40

3

20

High-throughput

0.871

High

475542

K1C19
Keratin, type I cytoskeletal 19

3

20

High-throughput

0.843

High

618011

K1C15
Keratin, type I cytoskeletal 15

2

20

High-throughput

0.817

High

300318

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.783

High

300557

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.783

High

300636

KRT37
Keratin, type I cuticular Ha7

2

20

High-throughput

0.783

High

385067

K1C14
Keratin, type I cytoskeletal 14

2

20

High-throughput

0.783

High

476281

K1C16
Keratin, type I cytoskeletal 16

2

20

High-throughput

0.783

High

876469

KT33B
Keratin, type I cuticular Ha3-II

2

20

High-throughput

0.783

High

876478

K1C24
Keratin, type I cytoskeletal 24

2

20

High-throughput

0.783

High

876486

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

876487

K1C26
Keratin, type I cytoskeletal 26

2

20

High-throughput

0.783

High

876488

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

876494

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

876459

K1C17
Keratin, type I cytoskeletal 17

2

20

High-throughput

0.754

High

566250

K1C13
Keratin, type I cytoskeletal 13

2

20

High-throughput

0.754

High

876497

KIFC3
Kinesin-like protein KIFC3

3

8

High-throughput

0.675

High

49888

A1A4E9
Keratin 13

1

20

High-throughput

0.665

High

876485

K1C28
Keratin, type I cytoskeletal 28

1

20

High-throughput

0.621

High

341750

K2C75
Keratin, type II cytoskeletal 75

1

20

High-throughput

0.618

High

385249

K2C6A
Keratin, type II cytoskeletal 6A

1

19

High-throughput

0.618

High

437121

K2C8
Keratin, type II cytoskeletal 8

1

19

High-throughput

0.618

High

474542

VIME
Vimentin

1

20

High-throughput

0.618

High

475747

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.618

High

566343

K2C5
Keratin, type II cytoskeletal 5

1

19

High-throughput

0.618

High

606090

DESM
Desmin

1

20

High-throughput

0.618

High

777381

K1C20
Keratin, type I cytoskeletal 20

1

20

High-throughput

0.618

High

833237

PERI
Peripherin

1

20

High-throughput

0.618

High

876506

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

876500

TRI54
Tripartite motif-containing protein 54

3

20

High-throughput

0.616

High

876479

LARP7
La-related protein 7

2

10

High-throughput

0.584

High

876460

ACTN3
Alpha-actinin-3

2

0

High-throughput

0.580

High

563408

CFTR
Cystic fibrosis transmembrane conductance regulator

1

15

High-throughput

0.536

High

876464

CUL1
Cullin-1

1

20

High-throughput

0.536

High

876465

CUL2
Cullin-2

1

20

High-throughput

0.536

High

876495

CSN5
COP9 signalosome complex subunit 5

1

14

High-throughput

0.536

High

876461

GOGA2
Golgin subfamily A member 2

1

7

High-throughput

0.523

High

876508

TFP11
Tuftelin-interacting protein 11

1

4

High-throughput

0.523

High

876475

PLEC
Plectin

1

18

High-throughput

0.515

High

876462

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

High-throughput

0.494

High

488745

FURIN
Furin

1

0

High-throughput

0.493

High

876504

P63
Tumor protein 63

1

6

Small-scale

0.489

High

131360

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

9

Small-scale

0.479

High

136336

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

18

High-throughput

0.479

High

187313

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

7

High-throughput

0.479

High

349003

LATS1
Serine/threonine-protein kinase LATS1

1

6

High-throughput

0.479

High

484989

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

High-throughput

0.479

High

651220

CBL
E3 ubiquitin-protein ligase CBL

1

11

High-throughput

0.479

High

876456

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

6

High-throughput

0.479

High

876468

DCTN1
Dynactin subunit 1

1

15

High-throughput

0.479

High

876471

CUL7
Cullin-7

1

4

High-throughput

0.479

High

876473

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

876474

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

14

High-throughput

0.479

High

876482

RICTR
Rapamycin-insensitive companion of mTOR

1

5

High-throughput

0.479

High

876499

ACE2
Angiotensin-converting enzyme 2

1

5

High-throughput

0.479

High

876503

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

738

MEIKN
Meiosis-specific kinetochore protein

1

1

High-throughput

0.470

High

876457

TPIS
Triosephosphate isomerase

1

0

Small-scale

0.458

High

876511

FBX7
F-box only protein 7

1

0

High-throughput

0.458

High

876498

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

Small-scale

0.457

High

327862

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.445

High

342790

HERC2
E3 ubiquitin-protein ligase HERC2

1

2

High-throughput

0.445

High

767130

MERL
Merlin

1

1

High-throughput

0.445

High

876458

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

876490

KIBRA
Protein KIBRA

1

17

High-throughput

0.445

High

876491

PALS1
Protein PALS1

1

2

High-throughput

0.445

High

876493

INADL
InaD-like protein

1

4

High-throughput

0.445

High

876502

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

876505

PDLI7
PDZ and LIM domain protein 7

1

1

High-throughput

0.445

High

876507

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.445

High

105551

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

277281

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

293363

CD123
Translation initiation factor eIF2 assembly protein

1

7

High-throughput

0.437

High

324639

HEXI1
Protein HEXIM1

1

16

High-throughput

0.437

High

635245

EFNA1
Ephrin-A1

1

19

High-throughput

0.437

High

876454

EFNA3
Ephrin-A3

1

19

High-throughput

0.437

High

876455

EFNA4
Ephrin-A4

1

19

High-throughput

0.437

High

876463

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

18

High-throughput

0.437

High

876466

DX39B
Spliceosome RNA helicase DDX39B

1

18

High-throughput

0.437

High

876470

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

18

High-throughput

0.437

High

876472

SLMAP
Sarcolemmal membrane-associated protein

1

6

High-throughput

0.437

High

876477

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.437

High

876483

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

876484

MEPCE
7SK snRNA methylphosphate capping enzyme

1

10

High-throughput

0.437

High

876492

FBXL6
F-box/LRR-repeat protein 6

1

1

Small-scale

0.437

High

876501

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

8

Small-scale

0.437

High

876509

PHTF1
Protein PHTF1

1

8

High-throughput

0.437

High

653186

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

876467

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

6

High-throughput

0.407

High

876480

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.407

High

876489

SULF2
Extracellular sulfatase Sulf-2

1

8

High-throughput

0.407

High

876496

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

8

High-throughput

0.407

High

876510

RPH3L
Rab effector Noc2

1

0

High-throughput

0.269

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025