HitPredict

Interactor 1: PBX1 (P40424)
Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL)
Gene: PBX1

Interactor 2: PKNX1 (P55347)
Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1)
Gene: PKNOX1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 26971355, 9482740, 26186194, 28514442, 10654609, 33961781, 35914814, 21900201, 25856340, 20211142, 19559479
Identification Methods affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, molecular sieving, ion exchange chromatography, comigration in sds page, two hybrid array, two hybrid fragment pooling approach
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Homeobox_KN~Homeobox_KN
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity
GO:0005634 - nucleus
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024