Protein: PITX1
Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1)

Gene: PITX1
Organism: Homo sapiens
Interactions: 131
UniProt ID: P78337

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001501 - skeletal system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

256528

TBX19
T-box transcription factor TBX19

2

9

High-throughput

0.783

High

772141

MSX2
Homeobox protein MSX-2

2

19

High-throughput

0.783

High

885214

HXA1
Homeobox protein Hox-A1

2

20

High-throughput

0.783

High

1005657

TBX22
T-box transcription factor TBX22

2

7

High-throughput

0.783

High

1005627

RBPMS
RNA-binding protein with multiple splicing

6

1

High-throughput

0.744

High

158965

CDX4
Homeobox protein CDX-4

1

20

High-throughput

0.698

High

1005638

RHXF2
Rhox homeobox family member 2

1

18

High-throughput

0.698

High

700820

PIT1
Pituitary-specific positive transcription factor 1

1

19

Small-scale

0.680

High

318131

IPO13
Importin-13

3

9

High-throughput

0.667

High

1005626

DVL3
Segment polarity protein dishevelled homolog DVL-3

3

2

High-throughput

0.667

High

783234

TRI23
E3 ubiquitin-protein ligase TRIM23

3

0

High-throughput

0.639

High

1005637

SPAG8
Sperm-associated antigen 8

3

0

High-throughput

0.639

High

1005658

MAGD1
Melanoma-associated antigen D1

3

0

High-throughput

0.639

High

224967

TLX3
T-cell leukemia homeobox protein 3

1

18

High-throughput

0.618

High

1005590

TBR1
T-box brain protein 1

1

9

High-throughput

0.618

High

1005635

PITX2
Pituitary homeobox 2

1

17

High-throughput

0.618

High

1005629

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

5

High-throughput

0.611

High

67544

MYH7B
Myosin-7B

2

1

High-throughput

0.606

High

71103

VGLL3
Transcription cofactor vestigial-like protein 3

2

1

High-throughput

0.606

High

590403

GATA1
Erythroid transcription factor

2

4

High-throughput

0.606

High

1005577

ARI5A
AT-rich interactive domain-containing protein 5A

2

16

High-throughput

0.606

High

1005578

TLE5
TLE family member 5

2

15

High-throughput

0.606

High

1005582

TP53B
TP53-binding protein 1

2

3

High-throughput

0.606

High

1005583

TRAF1
TNF receptor-associated factor 1

2

2

High-throughput

0.606

High

1005585

PTK6
Protein-tyrosine kinase 6

2

7

High-throughput

0.606

High

1005587

LASP1
LIM and SH3 domain protein 1

2

3

High-throughput

0.606

High

1005610

DZIP3
E3 ubiquitin-protein ligase DZIP3

2

3

High-throughput

0.606

High

1005632

TEKT5
Tektin-5

2

1

High-throughput

0.606

High

1005634

PFD5
Prefoldin subunit 5

2

1

High-throughput

0.606

High

1005650

PLS3
Phospholipid scramblase 3

2

3

High-throughput

0.606

High

1005653

SRGEF
Secretion-regulating guanine nucleotide exchange factor

2

1

High-throughput

0.606

High

872186

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

1005656

ZBT32
Zinc finger and BTB domain-containing protein 32

2

8

High-throughput

0.584

High

63590

PSB11
Proteasome subunit beta type-11

2

0

High-throughput

0.580

High

943642

SIK1
Serine/threonine-protein kinase SIK1

2

0

High-throughput

0.580

High

1005599

ACTMP
Actin maturation protease

2

0

High-throughput

0.580

High

1005607

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.580

High

1005616

STH
Saitohin

2

0

High-throughput

0.580

High

1005654

HSF4
Heat shock factor protein 4

2

0

High-throughput

0.580

High

1005655

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.580

High

50324

F168B
Myelin-associated neurite-outgrowth inhibitor

2

1

High-throughput

0.553

High

70172

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

300336

KRT34
Keratin, type I cuticular Ha4

2

6

High-throughput

0.553

High

351526

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

2

High-throughput

0.553

High

424592

PAI1
Plasminogen activator inhibitor 1

2

3

High-throughput

0.553

High

1005569

KRT83
Keratin, type II cuticular Hb3

2

3

High-throughput

0.553

High

1005576

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

2

5

High-throughput

0.553

High

1005591

KRA61
Keratin-associated protein 6-1

2

1

High-throughput

0.553

High

1005592

KRA62
Keratin-associated protein 6-2

2

1

High-throughput

0.553

High

1005594

KR195
Keratin-associated protein 19-5

2

1

High-throughput

0.553

High

1005595

KR197
Keratin-associated protein 19-7

2

2

High-throughput

0.553

High

1005597

KR132
Keratin-associated protein 13-2

2

2

High-throughput

0.553

High

1005603

UFSP1
Ufm1-specific protease 1

2

1

High-throughput

0.553

High

1005613

KRA81
Keratin-associated protein 8-1

2

1

High-throughput

0.553

High

1005614

KRA71
Keratin-associated protein 7-1

2

1

High-throughput

0.553

High

1005622

F168A
Protein FAM168A

2

1

High-throughput

0.553

High

1005641

KRA33
Keratin-associated protein 3-3

2

1

High-throughput

0.553

High

1005652

ANR10
Ankyrin repeat domain-containing protein 10

2

8

High-throughput

0.553

High

2892

A0A0C4DGF1
Zinc finger and BTB domain containing 32

2

1

High-throughput

0.544

High

180504

PLS1
Phospholipid scramblase 1

1

3

High-throughput

0.541

High

1005611

RFX6
DNA-binding protein RFX6

1

1

High-throughput

0.541

High

230001

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

4

High-throughput

0.536

High

1005574

PR20A
Proline-rich protein 20A

2

2

High-throughput

0.533

High

515693

TPC2B
Trafficking protein particle complex subunit 2B

1

0

Small-scale

0.529

High

1005579

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.523

High

1005608

Q86V38
Atrophin 1

1

17

High-throughput

0.515

High

1005651

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.513

High

612969

EGR1
Early growth response protein 1

1

7

Small-scale

0.501

High

903126

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

11

Small-scale

0.501

High

1005580

FOXO1
Forkhead box protein O1

1

18

Small-scale

0.501

High

1005584

STF1
Steroidogenic factor 1

1

16

Small-scale

0.501

High

169506

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

5

High-throughput

0.494

High

1005630

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.494

High

1005639

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.494

High

1005649

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

8

High-throughput

0.494

High

1005624

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

1005636

MDFI
MyoD family inhibitor

1

0

High-throughput

0.493

High

1005631

SAHH3
Adenosylhomocysteinase 3

1

4

High-throughput

0.489

High

928257

ATN1
Atrophin-1

1

20

High-throughput

0.481

High

1005617

ZNF34
Zinc finger protein 34

1

2

High-throughput

0.481

High

1005623

TSC1
Hamartin

1

4

High-throughput

0.481

High

142930

NFIB
Nuclear factor 1 B-type

1

18

High-throughput

0.479

High

170079

AURKA
Aurora kinase A

1

4

High-throughput

0.479

High

172693

XPO1
Exportin-1

1

9

High-throughput

0.479

High

473907

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

786535

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

886737

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.479

High

979482

H4
Histone H4

1

1

High-throughput

0.479

High

998195

H31
Histone H3.1

1

2

High-throughput

0.479

High

1005570

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.479

High

1005571

H33
Histone H3.3

1

2

High-throughput

0.479

High

1005575

EWS
RNA-binding protein EWS

1

6

High-throughput

0.479

High

1005581

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1005588

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1005621

SP7
Transcription factor Sp7

1

3

High-throughput

0.479

High

1005625

IRF7
Interferon regulatory factor 7

1

1

Small-scale

0.479

High

1005633

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1005640

KLF16
Krueppel-like factor 16

1

5

High-throughput

0.479

High

1005642

P63
Tumor protein 63

1

5

Small-scale

0.479

High

1005643

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1005645

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1005647

WDR6
tRNA

1

4

High-throughput

0.479

High

109169

G4XUV3
Putative hydroxypyruvate isomerase

1

1

High-throughput

0.470

High

1005573

PR20D
Proline-rich protein 20D

1

2

High-throughput

0.470

High

1005609

Q86WV8
TSC complex subunit 1

1

2

High-throughput

0.470

High

1005615

Q8IV28
Nidogen-2

1

1

High-throughput

0.470

High

1005646

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.460

High

1005586

NID2
Nidogen-2

1

1

High-throughput

0.439

High

1005601

HYI
Putative hydroxypyruvate isomerase

1

1

High-throughput

0.439

High

1005612

KR131
Keratin-associated protein 13-1

1

2

High-throughput

0.439

High

1005572

PR20C
Proline-rich protein 20C

1

2

High-throughput

0.417

High

192075

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.316

High

298159

DCTN3
Dynactin subunit 3

2

0

High-throughput

0.316

High

506779

NHLC4
NHL-repeat-containing protein 4

2

0

High-throughput

0.316

High

820620

CEAM6
Cell adhesion molecule CEACAM6

2

0

High-throughput

0.316

High

1005589

S15A2
Solute carrier family 15 member 2

2

0

High-throughput

0.316

High

1005598

KLH26
Kelch-like protein 26

2

0

High-throughput

0.316

High

1005600

CJ055
Uncharacterized protein C10orf55

2

0

High-throughput

0.316

High

1005602

CI057
Uncharacterized protein C9orf57

2

0

High-throughput

0.316

High

1005605

KR261
Keratin-associated protein 26-1

2

0

High-throughput

0.316

High

1005606

IGFL2
Insulin growth factor-like family member 2

2

0

High-throughput

0.316

High

1005618

MET27
Methyltransferase-like protein 27

2

0

High-throughput

0.316

High

1005619

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

2

0

High-throughput

0.316

High

1005620

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

1005628

PKHB2
Pleckstrin homology domain-containing family B member 2

2

0

High-throughput

0.316

High

1005644

CFA68
Cilia- and flagella-associated protein 68

2

0

High-throughput

0.316

High

1005648

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.316

High

1005596

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

2

0

High-throughput

0.304

High

1005604

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.282

High

1005593

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

959460

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025