Interactor 1: MLH1 (P40692)
DNA mismatch repair protein Mlh1 (MutL protein homolog 1)
Gene: MLH1

Interactor 2: MSH6 (P52701)
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)
Gene: MSH6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.902

The method score is based on:

Property Details
Experiments 10783165, 10748159, 12799449, 30770470, 37094360
Identification Methods biochemical, affinity chromatography technology
Interaction Type association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains HATPase_c_3~MutS_II, HATPase_c_3~MutS_III, HATPase_c_3~MutS_V
Common GO terms GO:0003682 - chromatin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006298 - mismatch repair
and 7 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 756
Hs

1 1360
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024