HitPredict

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14968112
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0016310 - phosphorylation GO:0042127 - regulation of cell population proliferation GO:0051092 - positive regulation of NF-kappaB transcription factor activity and 1 others more... GO:0097009 - energy homeostasis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 1620
+	Hs
		434150 STAT3_HUMAN (1-770): 0: 1048: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		601474 STAT3_HUMAN (1-770): 0: 1048: 100.00		FGFR2_HUMAN (952-1433): 9.52e-123: 407: 25.24
+	Hs
		776597 STAT3_HUMAN (1-770): 0: 1048: 100.00		ABL2_HUMAN (1103-1526): 1.55e-118: 405: 32.47
+	Hs
		609197 STAT3_HUMAN (1-770): 0: 1048: 100.00		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		507894 STAT3_HUMAN (1-770): 0: 1048: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Mm
		786524 STAT3_MOUSE (1-770): 0: 1049: 99.87		TIE2_MOUSE (954-1389): 3.85e-115: 394: 28.79
+	Hs
		411328 STAT3_HUMAN (1-770): 0: 1048: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435568 STAT3_HUMAN (1-770): 0: 1048: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		776680 STAT3_HUMAN (1-770): 0: 1048: 100.00		FAK2_HUMAN (1054-1518): 4.66e-109: 374: 27.45
+	Rn
		94369 F1M9D6_RAT (1-749): 0: 935: 51.71		INSR_RAT (973-1484): 1.45e-112: 392: 32.38
+	Hs
		384414 STAT3_HUMAN (1-770): 0: 1048: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Mm
		786520 STAT3_MOUSE (1-770): 0: 1049: 99.87		FER_MOUSE (1101-1376): 2.58e-61: 228: 41.20
+	Hs
		426949 STAT3_HUMAN (1-770): 0: 1048: 100.00		FES_HUMAN (1114-1384): 4.5e-59: 222: 42.80
+	Hs
		849893 STA5B_HUMAN (1-734): 0: 752: 30.55		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		384428 STAT1_HUMAN (1-749): 0: 929: 51.52		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		601481 STA5B_HUMAN (1-734): 0: 752: 30.55		FGFR2_HUMAN (952-1433): 9.52e-123: 407: 25.24
+	Hs
		601477 STA5A_HUMAN (1-734): 0: 745: 30.42		FGFR2_HUMAN (952-1433): 9.52e-123: 407: 25.24
+	Hs
		411341 STA5B_HUMAN (1-734): 0: 752: 30.55		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		411330 STA5A_HUMAN (1-734): 0: 745: 30.42		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		384522 STA5B_HUMAN (1-734): 0: 752: 30.55		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07