HitPredict

Interactor 1: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.737

Property	Details
Experiments	11429412, 20516148, 12804609, 18037959, 9724754, 21988832, 9388184
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0010629 - negative regulation of gene expression
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 628
+	Mm
		222290 STAT3_MOUSE (1-770): 0: 1049: 99.87		PIAS3_MOUSE (1-628): 0: 867: 96.98
+	Hs
		277977 STAT1_HUMAN (1-749): 0: 929: 51.52		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278282 STAT4_HUMAN (1-729): 0: 893: 48.44		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Dm
		1096412 STAT_DROME (1-755): 0: 648: 22.58		Q7KNF5_DROME (10-519): 3.43e-161: 475: 42.34