HitPredict

Interactor 1: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	29473952, 17353931, 33961781, 35271311, 36931259, 15324660, 28514442, 15161933
Identification Methods	x-ray crystallography, affinity chromatography technology, unspecified method, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, coimmunoprecipitation
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031647 - regulation of protein stability GO:0045296 - cadherin binding and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1118 Hs			1 245
+	Hs
		777027 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646698 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683179 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Mm
		910281 UBP8_MOUSE (1-1118): 0: 785: 81.04		1433E_MOUSE (2-241): 9.9e-144: 403: 68.18
+	Hs
		777025 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		777034 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		683881 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Hs
		647384 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		905375 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		905373 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		683244 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		259266 UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		910137 UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		905265 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		982625 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		904415 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		259272 UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		905377 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		259277 UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		905236 UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59