HitPredict

Interactor 1: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Interactor 2: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.690

Property	Details
Experiments	33961781, 36931259, 17979178, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1118 Hs			1 246
+	Hs
		777027 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	Hs
		777025 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Mm
		910281 UBP8_MOUSE (1-1118): 0: 785: 81.04		1433E_MOUSE (1-244): 1.37e-141: 398: 62.71
+	Hs
		777029 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		683179 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		646698 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		683881 UBP8_HUMAN (1-1118): 0: 830: 100.00		1433S_HUMAN (3-245): 2.76e-96: 283: 64.20
+	Hs
		905265 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Hs
		982625 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		1433F_HUMAN (1-246): 6.09e-136: 383: 100.00
+	Hs
		905373 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	Hs
		904415 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Hs
		259272 UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Hs
		905377 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		1433F_HUMAN (1-246): 6.09e-136: 383: 100.00
+	Hs
		259277 UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70		1433F_HUMAN (1-246): 6.09e-136: 383: 100.00
+	Hs
		910137 UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	Hs
		905236 UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Hs
		647384 UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		905375 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		683244 UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		259266 UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51