HitPredict

Interactor 1: MAD2 (P40958)
Mitotic spindle checkpoint component MAD2 (Mitotic MAD2 protein)
Gene: MAD2

Interactor 2: BUB1 (P41695)
Checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1)
Gene: BUB1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	27618268, 24402315
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000776 - kinetochore GO:0007094 - mitotic spindle assembly checkpoint signaling
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 196 Sc			1 1021
+	Hs
		236921 MD2L1_HUMAN (3-195): 3.25e-86: 254: 42.78		BUB1B_HUMAN (23-1012): 3.37e-129: 419: 15.58
+	Sp
		145599 MAD2_SCHPO (4-195): 1.74e-81: 242: 48.45		BUB1_SCHPO (20-989): 1.73e-121: 398: 24.11
+	Hs
		211011 MD2L1_HUMAN (3-195): 3.25e-86: 254: 42.78		BUB1_HUMAN (178-1016): 7.22e-101: 343: 17.22
+	Sc
		778483 MAD2_YEAST (1-196): 3.25e-88: 259: 100.00		MAD3_YEAST (21-464): 2.19e-102: 332: 29.08
+	Dm
		51409 Q9VRQ2_DROME (5-195): 3.58e-83: 246: 35.71		A1Z6I7_DROME (23-695): 8.13e-87: 308: 14.59
+	Sp
		145596 MAD2_SCHPO (4-195): 1.74e-81: 242: 48.45		MAD3_SCHPO (36-280): 1.56e-58: 205: 20.77
+	At
		187358 MAD2_ARATH (5-195): 1.86e-86: 255: 42.19		BUBR1_ARATH (24-308): 1.45e-26: 115: 17.30
+	Ce
		106146 Q9NGT3_CAEEL (4-195): 4.35e-81: 241: 40.21		G5EDL3_CAEEL (703-926): 5.23e-16: 82.3: 19.48