HitPredict

Interactor 1: RGS2 (P41220)
Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)
Gene: RGS2

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	16169070, 21900206
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005096 - GTPase activator activity GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0008277 - regulation of G protein-coupled receptor signaling pathway
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 211 Hs			1 761
+	Hs
		1329543 AXIN2_HUMAN (1-206): 2.56e-54: 187: 24.40		TNKS2_HUMAN (135-556): 6.36e-46: 179: 10.94
+	Hs
		170717 AXIN1_HUMAN (9-205): 3.02e-53: 184: 26.47		TNKS2_HUMAN (135-556): 6.36e-46: 179: 10.94
+	Hs
		310109 AXIN2_HUMAN (1-206): 2.56e-54: 187: 24.40		TNKS1_HUMAN (60-480): 1.04e-37: 154: 12.78
+	Hs
		170588 AXIN1_HUMAN (9-205): 3.02e-53: 184: 26.47		TNKS1_HUMAN (60-480): 1.04e-37: 154: 12.78
+	Mm
		956597 RGS14_MOUSE (80-197): 7.46e-17: 80.1: 35.83		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Mm
		103597 RGS14_MOUSE (80-197): 7.46e-17: 80.1: 35.83		ANK3_MOUSE (237-740): 1.36e-20: 99.9: 9.25