HitPredict

Interactor 1: P2RY2 (P41231)
P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor)
Gene: P2RY2

Interactor 2: AT2B3 (Q16720)
Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3)
Gene: ATP2B3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1220
+	Hs
		895636 CXCR4_HUMAN (7-329): 3.26e-75: 238: 23.85		AT2B3_HUMAN (1-1220): 0: 1287: 100.00
+	Hs
		966868 LPAR4_HUMAN (24-317): 2.74e-90: 277: 32.10		AT2B2_HUMAN (1-1220): 0: 1231: 81.07
+	Hs
		849665 CCR6_HUMAN (16-317): 1.12e-88: 273: 24.27		AT2B2_HUMAN (1-1220): 0: 1231: 81.07
+	Hs
		619214 CCR6_HUMAN (16-317): 1.12e-88: 273: 24.27		AT2B4_HUMAN (4-1220): 0: 1200: 71.89
+	Hs
		895608 CXCR4_HUMAN (7-329): 3.26e-75: 238: 23.85		AT2B2_HUMAN (1-1220): 0: 1231: 81.07
+	Hs
		588553 P2RY2_HUMAN (1-377): 2.25e-82: 257: 100.00		AT2B1_HUMAN (1-1220): 0: 1207: 78.94
+	Hs
		619207 P2RY2_HUMAN (1-377): 2.25e-82: 257: 100.00		AT2B4_HUMAN (4-1220): 0: 1200: 71.89
+	Hs
		428921 ADRB2_HUMAN (2-370): 2.36e-74: 238: 13.35		AT2B4_HUMAN (4-1220): 0: 1200: 71.89
+	Hs
		619229 GPR17_HUMAN (15-344): 1.13e-73: 235: 30.33		AT2B4_HUMAN (4-1220): 0: 1200: 71.89
+	Hs
		619204 APJ_HUMAN (2-345): 6.46e-73: 233: 22.73		AT2B4_HUMAN (4-1220): 0: 1200: 71.89
+	Hs
		849697 CCR6_HUMAN (16-317): 1.12e-88: 273: 24.27		AT2A3_HUMAN (51-1061): 0: 773: 25.28
+	Hs
		782452 P2RY2_HUMAN (1-377): 2.25e-82: 257: 100.00		AT2A3_HUMAN (51-1061): 0: 773: 25.28
+	Hs
		530845 P2RY2_HUMAN (1-377): 2.25e-82: 257: 100.00		AT1A3_HUMAN (39-1073): 0: 756: 23.47
+	Hs
		1031036 GPR17_HUMAN (15-344): 1.13e-73: 235: 30.33		AT2A3_HUMAN (51-1061): 0: 773: 25.28
+	Hs
		530862 CXCR4_HUMAN (7-329): 3.26e-75: 238: 23.85		AT1A3_HUMAN (39-1073): 0: 756: 23.47
+	Hs
		530883 GPR17_HUMAN (15-344): 1.13e-73: 235: 30.33		AT1A3_HUMAN (39-1073): 0: 756: 23.47
+	Hs
		392982 ADRB2_HUMAN (2-370): 2.36e-74: 238: 13.35		AT1A1_HUMAN (13-1073): 0: 751: 21.63
+	Hs
		428908 ADRB2_HUMAN (2-370): 2.36e-74: 238: 13.35		AT2A2_HUMAN (50-1075): 0: 750: 24.20
+	Hs
		561566 GPR17_HUMAN (15-344): 1.13e-73: 235: 30.33		AT2A2_HUMAN (50-1075): 0: 750: 24.20
+	Hs
		393214 P2RY6_HUMAN (21-333): 1.72e-72: 230: 39.05		AT1A1_HUMAN (13-1073): 0: 751: 21.63