Protein: RPF2
Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog)

Gene: RPF2
Organism: Homo sapiens
Interactions: 218
UniProt ID: Q9H7B2

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1140022

RRS1
Ribosome biogenesis regulatory protein homolog

4

3

High-throughput

0.900

High

1417562

MAK16
Protein MAK16 homolog

2

2

High-throughput

0.811

High

447451

NPM
Nucleophosmin

4

1

High-throughput

0.699

High

1435626

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.691

High

338190

NSA2
Ribosome biogenesis protein NSA2 homolog

3

2

High-throughput

0.667

High

898822

RL14
Large ribosomal subunit protein eL14

3

2

High-throughput

0.667

High

1037373

H11
Histone H1.1

3

3

High-throughput

0.667

High

1418587

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

2

High-throughput

0.667

High

290735

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.656

High

373158

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

905148

MECP2
Methyl-CpG-binding protein 2

3

0

High-throughput

0.638

High

841464

RBM34
RNA-binding protein 34

2

2

High-throughput

0.628

High

961842

RL37A
Large ribosomal subunit protein eL43

2

1

High-throughput

0.628

High

977085

CNBP
CCHC-type zinc finger nucleic acid binding protein

2

1

High-throughput

0.628

High

984545

RL30
Large ribosomal subunit protein eL30

2

1

High-throughput

0.628

High

1006715

SRPK2
SRSF protein kinase 2

2

3

High-throughput

0.628

High

1151198

OASL
2'-5'-oligoadenylate synthase-like protein

2

1

High-throughput

0.628

High

1416120

RBM4
RNA-binding protein 4

2

2

High-throughput

0.628

High

1435612

NOP53
Ribosome biogenesis protein NOP53

2

2

High-throughput

0.628

High

1435613

H2AW
Core histone macro-H2A.2

2

2

High-throughput

0.628

High

859457

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.618

High

521940

H14
Histone H1.4

2

3

High-throughput

0.611

High

596357

H12
Histone H1.2

2

3

High-throughput

0.611

High

986214

RL8
Large ribosomal subunit protein uL2

2

3

High-throughput

0.611

High

1161675

IF16
Gamma-interferon-inducible protein 16

2

1

High-throughput

0.611

High

1313149

ZC3H3
Zinc finger CCCH domain-containing protein 3

3

1

High-throughput

0.609

High

208382

RRP8
Ribosomal RNA-processing protein 8

2

0

High-throughput

0.602

High

1168573

KNOP1
Lysine-rich nucleolar protein 1

2

0

High-throughput

0.602

High

1361763

DGCR8
Microprocessor complex subunit DGCR8

2

0

High-throughput

0.602

High

96765

E9PAV9
G patch domain-containing protein 4

2

2

High-throughput

0.584

High

346335

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

4

High-throughput

0.584

High

1087553

GRSF1
G-rich sequence factor 1

2

2

High-throughput

0.584

High

1435624

SRPK3
SRSF protein kinase 3

2

2

High-throughput

0.574

High

396954

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1367283

ESR2
Estrogen receptor beta

2

1

High-throughput

0.571

High

129437

MEN1
Menin

2

0

High-throughput

0.559

High

1435601

ANLN
Anillin

2

0

High-throughput

0.559

High

1152419

DLG2
Disks large homolog 2

2

1

High-throughput

0.553

High

1126655

GRB7
Growth factor receptor-bound protein 7

2

0

High-throughput

0.547

High

74607

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

2

High-throughput

0.536

High

287137

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

4

High-throughput

0.536

High

288772

NPM3
Nucleoplasmin-3

1

1

High-throughput

0.536

High

301210

RL1D1
Ribosomal L1 domain-containing protein 1

1

5

High-throughput

0.536

High

428986

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

517706

ZBT48
Zinc finger and BTB domain-containing protein 48

1

1

High-throughput

0.536

High

685729

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.536

High

686434

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

785456

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.536

High

824362

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

833193

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.536

High

842538

RL35
Large ribosomal subunit protein uL29

1

2

High-throughput

0.536

High

855218

NOP2
28S rRNA

1

3

High-throughput

0.536

High

959965

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.536

High

960894

RL15
Large ribosomal subunit protein eL15

1

1

High-throughput

0.536

High

972567

RS14
Small ribosomal subunit protein uS11

1

2

High-throughput

0.536

High

975946

RL7A
Large ribosomal subunit protein eL8

1

4

High-throughput

0.536

High

984990

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.536

High

985888

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.536

High

1008889

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.536

High

1057909

RL18
Large ribosomal subunit protein eL18

1

2

High-throughput

0.536

High

1061150

SRSF1
Serine/arginine-rich splicing factor 1

1

3

High-throughput

0.536

High

1099253

SRSF5
Serine/arginine-rich splicing factor 5

1

4

High-throughput

0.536

High

1099537

SRSF6
Serine/arginine-rich splicing factor 6

1

6

High-throughput

0.536

High

1130850

RRP5
Protein RRP5 homolog

1

1

High-throughput

0.536

High

1137158

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

2

High-throughput

0.536

High

1402585

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.536

High

1409841

RBM4B
RNA-binding protein 4B

1

2

High-throughput

0.536

High

1413883

ZN692
Zinc finger protein 692

1

1

High-throughput

0.536

High

1428465

REXO4
RNA exonuclease 4

1

1

High-throughput

0.536

High

1435596

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.536

High

1435609

RBM28
RNA-binding protein 28

1

4

High-throughput

0.536

High

1435610

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.536

High

426576

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.515

High

1208811

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

1

High-throughput

0.515

High

338965

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.513

High

624150

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

788779

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

854303

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

860004

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

1245501

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.513

High

1310411

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1368240

CDKL2
Cyclin-dependent kinase-like 2

1

0

High-throughput

0.513

High

1390615

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1395820

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

1410732

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1435602

PRDM5
PR domain zinc finger protein 5

1

0

High-throughput

0.513

High

1435604

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

1435607

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

1435620

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

1435621

ZN346
Zinc finger protein 346

1

0

High-throughput

0.513

High

1435622

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

1435623

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.513

High

282309

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.493

High

891792

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.493

High

1068311

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.493

High

137483

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

1

High-throughput

0.489

High

649425

H1T
Histone H1t

1

3

High-throughput

0.489

High

1435617

ZBT47
Zinc finger and BTB domain-containing protein 47

1

1

High-throughput

0.489

High

260459

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

298450

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.479

High

406646

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

473085

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

620590

NUCL
Nucleolin

1

1

High-throughput

0.479

High

693981

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

810384

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

951855

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

953102

ACTB
Actin, cytoplasmic 1

1

3

High-throughput

0.479

High

969447

RS8
Small ribosomal subunit protein eS8

1

2

High-throughput

0.479

High

979245

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.479

High

1017213

H33
Histone H3.3

1

1

High-throughput

0.479

High

1106074

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.479

High

1117670

NOG2
Nucleolar GTP-binding protein 2

1

3

High-throughput

0.479

High

1127167

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

1215510

CE162
Centrosomal protein of 162 kDa

1

1

High-throughput

0.479

High

1215832

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1328957

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.479

High

1361236

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.479

High

1417475

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1435597

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1435599

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

1435600

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

1435608

NLE1
Notchless protein homolog 1

1

1

High-throughput

0.479

High

1435611

AATF
Protein AATF

1

1

High-throughput

0.479

High

1435625

CE164
Centrosomal protein of 164 kDa

1

1

High-throughput

0.479

High

194348

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

223335

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

274759

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.458

High

324214

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.458

High

386236

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.458

High

474294

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.458

High

589699

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696518

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

711191

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

High-throughput

0.458

High

714433

PML
Protein PML

1

0

High-throughput

0.458

High

731620

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

769190

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

831438

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

879465

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

954743

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.458

High

986729

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1035919

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1067720

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1089555

ILF2
Interleukin enhancer-binding factor 2

1

0

High-throughput

0.458

High

1107216

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1288255

LYRIC
Protein LYRIC

1

0

Small-scale

0.458

High

1290731

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1346932

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1352758

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1384879

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1393698

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1401703

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

1402305

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

1404764

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

1435595

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1435598

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1435605

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1435614

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1435618

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.458

High

994797

YBOX1
Y-box-binding protein 1

1

1

Small-scale

0.445

High

1130456

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

1212373

GPTC4
G patch domain-containing protein 4

1

2

High-throughput

0.445

High

1368720

DLG3
Disks large homolog 3

1

1

High-throughput

0.439

High

132302

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.437

High

348203

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

1

High-throughput

0.437

High

720326

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.437

High

993335

ACTG
Actin, cytoplasmic 2

1

3

High-throughput

0.437

High

996538

ACTS
Actin, alpha skeletal muscle

1

2

High-throughput

0.437

High

1088217

MERTK
Tyrosine-protein kinase Mer

1

1

High-throughput

0.437

High

1227468

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

430367

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

69979

A8KAG1
G patch domain-containing protein 4

1

2

High-throughput

0.407

High

376427

PDGFB
Platelet-derived growth factor subunit B

2

0

High-throughput

0.328

High

1412392

ZNF2
Zinc finger protein 2

2

0

High-throughput

0.328

High

1393161

PRR11
Proline-rich protein 11

2

0

High-throughput

0.318

High

272467

OBSL1
Obscurin-like protein 1

2

0

High-throughput

0.305

High

191805

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.279

Low

897163

TUB
Tubby protein homolog

1

0

High-throughput

0.279

Low

1127495

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1178089

RN151
RING finger protein 151

1

0

High-throughput

0.279

Low

1281475

ZN467
Zinc finger protein 467

1

0

High-throughput

0.279

Low

1290041

PNM8A
Paraneoplastic antigen-like protein 8A

1

0

High-throughput

0.279

Low

1290228

PIM3
Serine/threonine-protein kinase pim-3

1

0

High-throughput

0.279

Low

1329494

OTU6B
Deubiquitinase OTUD6B

1

0

High-throughput

0.279

Low

1395706

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

1398129

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

1398583

ZNF48
Zinc finger protein 48

1

0

High-throughput

0.279

Low

1435603

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

1

0

High-throughput

0.279

Low

1435619

IL17B
Interleukin-17B

1

0

High-throughput

0.279

Low

1435627

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

423181

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

125612

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

157858

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

320057

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

457705

TBB5
Tubulin beta chain

1

0

High-throughput

0.249

Low

564851

NCAM1
Neural cell adhesion molecule 1

1

0

High-throughput

0.249

Low

680746

CATS
Cathepsin S

1

0

High-throughput

0.249

Low

910200

RND2
Rho-related GTP-binding protein RhoN

1

0

High-throughput

0.249

Low

955859

DEST
Destrin

1

0

High-throughput

0.249

Low

971087

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1126179

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1135107

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1140871

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1255559

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1293152

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1322448

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

1385868

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low

1388408

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.249

Low

1416681

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

1418449

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

1419417

RHBT2
Rho-related BTB domain-containing protein 2

1

0

High-throughput

0.249

Low

1431538

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.249

Low

1432623

MTRFR
Mitochondrial translation release factor in rescue

1

0

High-throughput

0.249

Low

1435606

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

1435615

C2D2A
Coiled-coil and C2 domain-containing protein 2A

1

0

High-throughput

0.249

Low

328160

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.232

Low

1214196

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1335723

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1435616

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025