HitPredict

Interactor 1: HNF4A (P41235)
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Gene: HNF4A

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 474 Hs			1 1424
+	Hs
		782560 HNF4A_HUMAN (1-474): 0: 542: 100.00		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		587212 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		782551 HNF4A_HUMAN (1-474): 0: 542: 100.00		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		126108 HNF4A_HUMAN (1-474): 0: 542: 100.00		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		490120 COT1_HUMAN (22-386): 4.95e-116: 349: 33.60		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Mm
		985528 HNF4G_MOUSE (52-456): 1.18e-138: 406: 74.57		Q05BA5_MOUSE (1-1424): 1.37e-137: 460: 80.73
+	Mm
		60499 HNF4G_MOUSE (52-456): 1.18e-138: 406: 74.57		A5D6Q2_MOUSE (50-1424): 1.18e-129: 437: 80.69
+	Hs
		782555 HNF4A_HUMAN (1-474): 0: 542: 100.00		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		649056 HNF4A_HUMAN (1-474): 0: 542: 100.00		ARNT_HUMAN (6-642): 2.95e-76: 272: 16.01
+	Hs
		587195 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		NPAS2_HUMAN (19-807): 7.51e-111: 372: 16.20
+	Hs
		587173 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		126103 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		490101 COT1_HUMAN (22-386): 4.95e-116: 349: 33.60		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		1055255 HNF4G_HUMAN (52-456): 5.67e-137: 402: 73.58		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		181498 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		587177 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Dm
		836362 HNF4_DROME (57-428): 1.36e-119: 367: 60.57		SIMA_DROME (6-845): 1.83e-74: 276: 12.24
+	Hs
		659718 RXRB_HUMAN (16-377): 3.43e-119: 360: 38.03		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		782595 HNF4A_HUMAN (1-474): 0: 542: 100.00		KMT2C_HUMAN (471-1383): 2.87e-11: 70.9: 12.87
+	Hs
		490089 COT1_HUMAN (22-386): 4.95e-116: 349: 33.60		AHR_HUMAN (12-793): 4.1e-70: 255: 12.66