HitPredict

Interactor 1: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27880917, 28675297
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Hs			1 780
+	Hs
		441186 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		782837 CSK_HUMAN (1-450): 0: 543: 100.00		PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01
+	Mm
		782850 CSK_MOUSE (1-450): 0: 543: 99.11		PTN18_MOUSE (2-446): 8.05e-136: 411: 32.97
+	Hs
		616905 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		441169 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		337361 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		522804 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		337339 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Mm
		337619 ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83		PTN11_MOUSE (7-351): 2.04e-124: 387: 31.48
+	Hs
		522755 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		522931 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		522754 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTN2_HUMAN (24-401): 2.72e-123: 377: 23.85
+	Hs
		522756 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PTPRA_HUMAN (7-295): 5.6e-105: 342: 32.08
+	Dm
		337644 ABL_DROME (5-447): 1.98e-163: 502: 38.11		LAR_DROME (8-302): 1.8e-92: 319: 30.33
+	Dm
		337643 ABL_DROME (5-447): 1.98e-163: 502: 38.11		PTP69_DROME (7-298): 8.96e-74: 264: 26.25
+	Hs
		782790 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64
+	Hs
		617084 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		782792 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRO_HUMAN (58-303): 3.31e-46: 180: 38.71
+	Hs
		782783 CSK_HUMAN (1-450): 0: 543: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Dm
		337647 ABL_DROME (5-447): 1.98e-163: 502: 38.11		PTP99_DROME (10-319): 2.98e-44: 174: 21.07