HitPredict

Interactor 1: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Interactor 2: TENS2 (Q63HR2)
Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)
Gene: TNS2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.952

Property	Details
Experiments	27880917, 27432908, 28330616, 28675297, 32707033, 23455922
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, C1_1~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0008285 - negative regulation of cell population proliferation GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Hs			1 1409
+	Hs
		782797 CSK_HUMAN (1-450): 0: 543: 100.00		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Hs
		523025 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Rn
		222445 CSK_RAT (1-450): 0: 543: 98.44		PTEN_RAT (118-478): 7.3e-114: 365: 24.37
+	Hs
		433303 YES_HUMAN (12-442): 5.99e-170: 490: 37.30		PTEN_HUMAN (118-478): 6.4e-114: 365: 24.37
+	Rn
		222449 SRC_RAT (12-442): 2e-169: 488: 39.55		PTEN_RAT (118-478): 7.3e-114: 365: 24.37
+	Hs
		789107 FRK_HUMAN (5-442): 1.83e-167: 482: 36.17		PTEN_HUMAN (118-478): 6.4e-114: 365: 24.37
+	Hs
		433843 LYN_HUMAN (4-445): 3.75e-160: 463: 37.12		TPTE2_HUMAN (106-424): 9.56e-105: 345: 25.37
+	Dm
		1360391 SRC42_DROME (5-449): 3.09e-170: 489: 37.99		Q9VGK8_DROME (804-1253): 9.26e-43: 171: 14.82
+	Hs
		789030 TXK_HUMAN (10-443): 4.44e-159: 461: 36.75		TENS4_HUMAN (847-1409): 1.5e-44: 175: 32.50
+	Hs
		782828 CSK_HUMAN (1-450): 0: 543: 100.00		TENS1_HUMAN (427-1338): 2.81e-12: 74: 11.34
+	Dm
		337700 SRC64_DROME (13-443): 2.3e-150: 440: 35.49		Q9VGK8_DROME (804-1253): 9.26e-43: 171: 14.82
+	Hs
		337335 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		522749 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		411582 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Dm
		337683 SRC64_DROME (13-443): 2.3e-150: 440: 35.49		EGRAP_DROME (962-1247): 8.01e-41: 158: 20.55
+	Hs
		297808 LYN_HUMAN (4-445): 3.75e-160: 463: 37.12		K0754_HUMAN (949-1350): 3.11e-26: 120: 11.72
+	Hs
		433560 LYN_HUMAN (4-445): 3.75e-160: 463: 37.12		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		64077 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		L37A2_HUMAN (433-1142): 8.64e-12: 72.4: 9.19
+	Hs
		411823 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		ASPP1_HUMAN (749-1169): 6.23e-10: 66.1: 12.59
+	Hs
		433948 LYN_HUMAN (4-445): 3.75e-160: 463: 37.12		ASPP1_HUMAN (749-1169): 6.23e-10: 66.1: 12.59