Protein: EZH2
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2)

Gene: EZH2
Organism: Mus musculus
Interactions: 64
UniProt ID: Q61188

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1142289

EED
Polycomb protein EED

11

20

Small-scale

0.978

High

1142281

SUZ12
Polycomb protein Suz12

9

11

Small-scale

0.970

High

1141929

RBBP4
Histone-binding protein RBBP4

3

20

Small-scale

0.847

High

1141957

RBBP7
Histone-binding protein RBBP7

2

20

Small-scale

0.789

High

1142275

JARD2
Protein Jumonji

6

18

Small-scale

0.732

High

1142276

TLE1
Transducin-like enhancer protein 1

1

20

Small-scale

0.691

High

1142285

TRI35
E3 ubiquitin-protein ligase TRIM35

1

6

Small-scale

0.691

High

1142301

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

17

Small-scale

0.665

High

970680

MTF2
Metal-response element-binding transcription factor 2

3

20

Small-scale

0.656

High

1142303

AEBP2
Zinc finger protein AEBP2

3

19

Small-scale

0.656

High

936648

EZH1
Histone-lysine N-methyltransferase EZH1

1

19

Small-scale

0.618

High

1125426

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

16

Small-scale

0.618

High

1142271

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

Small-scale

0.618

High

140274

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.601

High

533907

DNMT1
DNA

2

20

Small-scale

0.601

High

1142293

DNM3L
DNA

1

13

Small-scale

0.586

High

1142294

PHF19
PHD finger protein 19

2

20

Small-scale

0.584

High

111411

J3QPN0
Zinc finger protein 518B

1

14

Small-scale

0.561

High

1142273

ATRX
Transcriptional regulator ATRX

1

20

Small-scale

0.561

High

57310

SETX
Probable helicase senataxin

1

7

Small-scale

0.536

High

822738

BRCA1
Breast cancer type 1 susceptibility protein homolog

1

14

Small-scale

0.536

High

1142282

NANOG
Homeobox protein NANOG

1

17

High-throughput

0.536

High

1142288

STK38
Serine/threonine-protein kinase 38

1

7

Small-scale

0.536

High

952747

H33
Histone H3.3

1

20

Small-scale

0.527

High

1142300

CITE4
Cbp/p300-interacting transactivator 4

1

0

High-throughput

0.518

High

1142299

RNF12
E3 ubiquitin-protein ligase RLIM

1

3

Small-scale

0.500

High

485947

MYOD1
Myoblast determination protein 1

1

5

Small-scale

0.481

High

70611

Z518A
Zinc finger protein 518A

1

14

Small-scale

0.479

High

102330

G3UWZ0
Bromodomain adjacent to zinc finger domain 1A

1

20

Small-scale

0.479

High

103032

G3X9H5
Huntingtin

1

2

Small-scale

0.479

High

139867

CLOCK
Circadian locomoter output cycles protein kaput

1

10

Small-scale

0.479

High

291338

WIZ
Protein Wiz

1

13

Small-scale

0.479

High

501130

H10
Histone H1.0

1

1

Small-scale

0.479

High

620844

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.479

High

956901

CRY1
Cryptochrome-1

1

1

Small-scale

0.479

High

958378

ARVC
Splicing regulator ARVCF

1

9

Small-scale

0.479

High

990819

H1T
Histone H1t

1

20

Small-scale

0.479

High

1142272

CBX5
Chromobox protein homolog 5

1

20

Small-scale

0.479

High

1142274

SSXT
Protein SSXT

1

14

Small-scale

0.479

High

1142277

RBL2
Retinoblastoma-like protein 2

1

9

Small-scale

0.479

High

1142278

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

4

Small-scale

0.479

High

1142279

LCOR
Ligand-dependent corepressor

1

5

Small-scale

0.479

High

1142280

EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

1

5

Small-scale

0.479

High

1142284

ASXL2
Putative Polycomb group protein ASXL2

1

12

Small-scale

0.479

High

1142286

H1FNT
Testis-specific H1 histone

1

1

Small-scale

0.479

High

1142287

NOC3L
Nucleolar complex protein 3 homolog

1

2

Small-scale

0.479

High

1142292

FOXP3
Forkhead box protein P3

1

5

Small-scale

0.479

High

1142295

Q9DCC5
Cbx3 protein

1

20

Small-scale

0.479

High

1142296

CUL3
Cullin-3

1

11

Small-scale

0.479

High

1142298

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

12

Small-scale

0.479

High

1142302

PHF1
PHD finger protein 1

1

20

Small-scale

0.479

High

291731

DNM3A
DNA

1

15

Small-scale

0.445

High

291747

DNM3B
DNA

1

15

Small-scale

0.445

High

962542

TYY1
Transcriptional repressor protein YY1

1

13

Small-scale

0.445

High

223220

PJA1
E3 ubiquitin-protein ligase Praja-1

1

1

Small-scale

0.437

High

862351

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

7

Small-scale

0.437

High

960488

HMMR
Hyaluronan mediated motility receptor

1

6

Small-scale

0.437

High

1112363

Q3U3J1
2-oxoisovalerate dehydrogenase subunit alpha

1

3

Small-scale

0.437

High

1142290

DDX27
Probable ATP-dependent RNA helicase DDX27

1

9

Small-scale

0.437

High

1142297

MY18A
Unconventional myosin-XVIIIa

1

5

Small-scale

0.437

High

100222

MORC3
MORC family CW-type zinc finger protein 3

1

0

Small-scale

0.426

High

1142291

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

2

Small-scale

0.407

High

1142283

VANG1
Vang-like protein 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024